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NLRP3 [cytosol]
Stable Identifier
R-HSA-561189
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NACHT, LRR and PYD domains-containing protein 3, NALP3_HUMAN, Cryopyrin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
ASC is recruited via a PYD-PYD interaction (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 activation by small molecules (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
The CARD domain of ASC recruits Procaspase-1 (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
ASC is recruited via a PYD-PYD interaction (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 activation by elicitor proteins (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 activation by small molecules (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 oligomerizes via NACHT domains (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP binds NLRP3 (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
TXNIP:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
The CARD domain of ASC recruits Procaspase-1 (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor proteins:NLRP3 [cytosol] (Homo sapiens)
NLRP3:SUGT1:HSP90 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRISC complex deubiquitinates NLRP3 (Homo sapiens)
BRISC complex:NLRP3 [cytosol] (Homo sapiens)
NLRP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96P20 NLRP3
Gene Names
NLRP3, C1orf7, CIAS1, NALP3, PYPAF1
Chain
chain:1-1036
Reference Genes
BioGPS Gene:114548 NLRP3
COSMIC (genes):NLRP3 NLRP3
CTD Gene:114548 NLRP3
dbSNP Gene:114548 NLRP3
ENSEMBL:ENSG00000162711 NLRP3
HGNC:16400 NLRP3
KEGG Gene (Homo sapiens):114548 NLRP3
Monarch:114548 NLRP3
NCBI Gene:114548 NLRP3
OMIM:606416 NLRP3
UCSC:Q96P20 NLRP3
Reference Transcript
RefSeq:XM_017000181.1 NLRP3
RefSeq:XM_017000183.1 NLRP3
RefSeq:NM_001243133.1 NLRP3
RefSeq:XM_017000184.1 NLRP3
RefSeq:NM_001079821.2 NLRP3
RefSeq:NM_183395.2 NLRP3
RefSeq:NM_004895.4 NLRP3
RefSeq:NM_001127461.2 NLRP3
RefSeq:XM_017000182.1 NLRP3
RefSeq:XM_011544048.2 NLRP3
RefSeq:NM_001127462.2 NLRP3
Other Identifiers
0000540278
0001240484
114548
11738183_a_at
11738523_a_at
16679697
207075_at
216015_s_at
216016_at
2390051
2390052
2390053
2390054
2390055
2390056
2390057
2390058
2390059
2390064
2390065
2390072
2390073
2390074
2390076
2390078
2390079
2390080
2390081
2390082
2390083
2390084
2390085
2390086
33598_r_at
7911178
A_14_P105324
A_33_P3281695
GE81454
GO:0000139
GO:0000166
GO:0002374
GO:0002376
GO:0002523
GO:0002674
GO:0002830
GO:0003674
GO:0003677
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005829
GO:0006464
GO:0006810
GO:0006915
GO:0006919
GO:0006950
GO:0006952
GO:0006954
GO:0007155
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008219
GO:0009058
GO:0009595
GO:0014070
GO:0015031
GO:0016020
GO:0016579
GO:0022607
GO:0030154
GO:0032088
GO:0032611
GO:0032612
GO:0032621
GO:0032691
GO:0032731
GO:0032736
GO:0032753
GO:0032754
GO:0032991
GO:0034641
GO:0040011
GO:0042802
GO:0042834
GO:0043167
GO:0043226
GO:0043280
GO:0043565
GO:0044546
GO:0045087
GO:0045471
GO:0045630
GO:0045944
GO:0048856
GO:0048870
GO:0050727
GO:0050728
GO:0050830
GO:0051092
GO:0051607
GO:0061702
GO:0065003
GO:0071222
GO:0071224
GO:0072559
GO:1901223
GO:2000321
GO:2000553
Hs.159483.1.S1_3p_a_at
Hs.159483.1.S1_3p_at
ILMN_1696933
ILMN_1712026
ILMN_1713379
ILMN_2310896
PH_hs_0029274
TC01002008.hg
g4757727_3p_at
Participant Of
hasComponent
BRISC complex:NLRP3 [cytosol]
NLRP3 elicitor small molecules:NLRP3 [cytosol]
NLRP3:SUGT1:HSP90 [cytosol]
TXNIP:NLRP3 [cytosol]
output
Expression of NLRP3 gene
input
SGT1:HSP90 binds inactive NLRP3
TXNIP binds NLRP3
Other forms of this molecule
K63polyUb-NLRP3 [cytosol]
Inferred To
Homologues of NLRP3 [cytosol] (Danio rerio)
Nlrp3 [cytosol] (Mus musculus)
Nlrp3 [cytosol] (Rattus norvegicus)
nlrb5 [cytosol] (Danio rerio)
NLRP3 [cytosol] (Bos taurus)
NLRP3 [cytosol] (Canis familiaris)
NLRP3 [cytosol] (Sus scrofa)
Ghost homologue of NLRP3 [cytosol] (Gallus gallus)
Ghost homologue of NLRP3 [cytosol] (Xenopus tropicalis)
LOC103910107 [cytosol] (Danio rerio)
Cross References
RefSeq
XP_016855673.1
,
NP_001073289.1
,
XP_016855671.1
,
NP_001120933.1
,
NP_001120934.1
,
XP_011542350.1
,
NP_001230062.1
,
XP_016855670.1
,
NP_004886.3
,
XP_016855672.1
,
NP_899632.1
OpenTargets
ENSG00000162711
HPA
ENSG00000162711-NLRP3
GeneCards
Q96P20
Ensembl
ENSP00000375704
,
ENSP00000375703
,
ENST00000348069
,
ENST00000391827
,
ENST00000474792
,
ENSP00000355452
,
ENSP00000355453
,
ENST00000391828
,
ENSP00000337383
,
ENSP00000493674
,
ENST00000643234
,
ENST00000366497
,
ENSP00000294752
,
ENST00000366496
,
ENST00000336119
,
ENSP00000493937
,
ENSG00000162711
PRO
Q96P20
Orphanet
16553
PDB
2NAQ
,
6NPY
,
3QF2
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.86
10
UniProt:Q8TDX7 NEK7
2
NEK7 [cytosol]
(R-HSA-2530599)
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
0.675
4
UniProt:P19525 EIF2AK2
1
EIF2AK2 [cytosol]
(R-HSA-168699)
0.602
6
UniProt:Q96P20 NLRP3
2
NLRP3 [cytosol]
(R-HSA-561189)
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
0.573
2
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.556
4
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
UniProt:P36957 DLST
2
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.556
3
UniProt:Q9ES74 NEK7
0.524
2
UniProt:Q80H93 8b
1
8b [cytosol]
(R-COV-9678168)
0.463
7
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