Reactome | NLRP3 [cytosol]

NLRP3 [cytosol]

Stable Identifier

R-HSA-561189

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NACHT, LRR and PYD domains-containing protein 3, NALP3_HUMAN, Cryopyrin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96P20 NLRP3

Gene Names

NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Chain

chain:1-1036

Reference Genes

BioGPS Gene:114548 NLRP3

COSMIC (genes):NLRP3 NLRP3

CTD Gene:114548 NLRP3

dbSNP Gene:114548 NLRP3

ENSEMBL:ENSG00000162711 NLRP3

HGNC:16400 NLRP3

KEGG Gene (Homo sapiens):114548 NLRP3

Monarch:114548 NLRP3

NCBI Gene:114548 NLRP3

OMIM:606416 NLRP3

UCSC:Q96P20 NLRP3

Reference Transcript

Other Identifiers

0000540278

0001240484

114548

11738183_a_at

11738523_a_at

16679697

207075_at

216015_s_at

216016_at

2390051

2390052

2390053

2390054

2390055

2390056

2390057

2390058

2390059

2390064

2390065

2390072

2390073

2390074

2390076

2390078

2390079

2390080

2390081

2390082

2390083

2390084

2390085

2390086

33598_r_at

7911178

A_14_P105324

A_33_P3281695

GE81454

GO:0000139

GO:0000166

GO:0002374

GO:0002376

GO:0002523

GO:0002674

GO:0002830

GO:0003674

GO:0003677

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0006464

GO:0006810

GO:0006915

GO:0006919

GO:0006950

GO:0006952

GO:0006954

GO:0007155

GO:0007165

GO:0007267

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009595

GO:0014070

GO:0015031

GO:0016020

GO:0016579

GO:0022607

GO:0030154

GO:0032088

GO:0032611

GO:0032612

GO:0032621

GO:0032691

GO:0032731

GO:0032736

GO:0032753

GO:0032754

GO:0032991

GO:0034641

GO:0040011

GO:0042802

GO:0042834

GO:0043167

GO:0043226

GO:0043280

GO:0043565

GO:0044546

GO:0045087

GO:0045471

GO:0045630

GO:0045944

GO:0048856

GO:0048870

GO:0050727

GO:0050728

GO:0050830

GO:0051092

GO:0051607

GO:0061702

GO:0065003

GO:0071222

GO:0071224

GO:0072559

GO:1901223

GO:2000321

GO:2000553

Hs.159483.1.S1_3p_a_at

Hs.159483.1.S1_3p_at

ILMN_1696933

ILMN_1712026

ILMN_1713379

ILMN_2310896

PH_hs_0029274

TC01002008.hg

g4757727_3p_at

Participant Of

hasComponent

output

Expression of NLRP3 gene

input

Other forms of this molecule

K63polyUb-NLRP3 [cytosol]

Inferred To

Homologues of NLRP3 [cytosol] (Danio rerio)

Nlrp3 [cytosol] (Mus musculus)

Nlrp3 [cytosol] (Rattus norvegicus)

nlrb5 [cytosol] (Danio rerio)

NLRP3 [cytosol] (Bos taurus)

NLRP3 [cytosol] (Canis familiaris)

NLRP3 [cytosol] (Sus scrofa)

Ghost homologue of NLRP3 [cytosol] (Gallus gallus)

Ghost homologue of NLRP3 [cytosol] (Xenopus tropicalis)

LOC103910107 [cytosol] (Danio rerio)

Cross References

RefSeq

XP_016855673.1, NP_001073289.1, XP_016855671.1, NP_001120933.1, NP_001120934.1, XP_011542350.1, NP_001230062.1, XP_016855670.1, NP_004886.3, XP_016855672.1, NP_899632.1

OpenTargets

ENSG00000162711

HPA

ENSG00000162711-NLRP3

GeneCards

Q96P20

Ensembl

ENSP00000375704, ENSP00000375703, ENST00000348069, ENST00000391827, ENST00000474792, ENSP00000355452, ENSP00000355453, ENST00000391828, ENSP00000337383, ENSP00000493674, ENST00000643234, ENST00000366497, ENSP00000294752, ENST00000366496, ENST00000336119, ENSP00000493937, ENSG00000162711

PRO

Q96P20

Orphanet

16553

PDB

2NAQ, 6NPY, 3QF2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [cytosol] (R-HSA-561191) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.86	10
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.675	4
UniProt:P19525 EIF2AK2	1	EIF2AK2 [cytosol] (R-HSA-168699)	0.602	6
UniProt:Q96P20 NLRP3	2	NLRP3 [cytosol] (R-HSA-561189) K63polyUb-NLRP3 [cytosol] (R-HSA-6783288)	0.573	2
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.556	4
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:Q9ES74 NEK7			0.524	2
UniProt:Q80H93 8b	1	8b [cytosol] (R-COV-9678168)	0.463	7

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