H2AFX [nucleoplasm]

Stable Identifier
R-HSA-56151
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H2A.x, H2a/x
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P16104 H2AFX
Gene Names
H2AFX, H2AX
Chain
initiator methionine:, chain:2-143
Reference Genes
BioGPS Gene:3014 H2AFX
COSMIC (genes):H2AFX H2AFX
CTD Gene:3014 H2AFX
dbSNP Gene:3014 H2AFX
ENSEMBL:ENSG00000188486 H2AFX
HGNC:4739 H2AFX
KEGG:hsa:3014 H2AFX
Monarch:3014 H2AFX
NCBI Gene:3014 H2AFX
OMIM:601772 H2AFX
UCSC:P16104 H2AFX
Reference Transcript
Other Identifiers
11754243_a_at
16745236
205436_PM_s_at
205436_s_at
212525_3p_s_at
212525_PM_s_at
212525_s_at
3014
3394184
3394185
3394186
3394187
3394188
3394189
3394190
40195_at
7952179
A_24_P38895
GE59719
GO:0000077
GO:0000228
GO:0000724
GO:0000781
GO:0000785
GO:0000786
GO:0000794
GO:0001673
GO:0001741
GO:0003677
GO:0003684
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006334
GO:0006974
GO:0007283
GO:0010212
GO:0016607
GO:0019899
GO:0021987
GO:0022414
GO:0030527
GO:0031492
GO:0031507
GO:0035861
GO:0042393
GO:0043226
GO:0043229
GO:0045739
GO:0046982
GO:0048856
GO:0051321
GO:0060090
GO:0065003
GO:0070062
GO:0071480
GO:0090398
GO:0090734
GO:0140463
GO:1990166
HMNXSV003055476
Hs.147097.1.A1_3p_a_at
ILMN_1785756
ILMN_2200331
PH_hs_0008797
PH_hs_0040597
TC11002362.hg
X14850_at
g4504252_3p_a_at
Participates
as a component of
as an input of
as a candidate of
Other forms of this molecule
p-Y143-H2AFX [nucleoplasm]
p-S140,Y143-H2AFX [nucleoplasm]
p-S140-H2AFX [nucleoplasm]
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
H2AFX [extracellular region]
Me2sR4-H2AFX [nucleoplasm]
Inferred To
LOC100485548 [nucleoplasm] (Xenopus tropicalis)
Homologues of H2AFX [nucleoplasm] (Caenorhabditis elegans)
Homologues of H2AFX [nucleoplasm] (Danio rerio)
Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
Homologues of H2AFX [nucleoplasm] (Drosophila melanogaster)
Homologues of H2AFX [nucleoplasm] (Gallus gallus)
Homologues of H2AFX [nucleoplasm] (Saccharomyces cerevisiae)
Homologues of H2AFX [nucleoplasm] (Schizosaccharomyces pombe)
Homologues of H2AFX [nucleoplasm] (Xenopus tropicalis)
LOC100487632 [nucleoplasm] (Xenopus tropicalis)
LOC116411633 [nucleoplasm] (Xenopus tropicalis)
his-35 [nucleoplasm] (Caenorhabditis elegans)
HTA1 [nucleoplasm] (Saccharomyces cerevisiae)
HTA2 [nucleoplasm] (Saccharomyces cerevisiae)
H2Av2 [nucleoplasm] (Dictyostelium discoideum)
H2AFX [nucleoplasm] (Gallus gallus)
H2AFX [nucleoplasm] (Plasmodium falciparum)
His2A:CG33862 [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of H2AFX [nucleoplasm] (Bos taurus)
hta1 [nucleoplasm] (Schizosaccharomyces pombe)
H2ax [nucleoplasm] (Rattus norvegicus)
his-65 [nucleoplasm] (Caenorhabditis elegans)
hta2 [nucleoplasm] (Schizosaccharomyces pombe)
h2ac16 [nucleoplasm] (Xenopus tropicalis)
LOC100859381 [nucleoplasm] (Gallus gallus)
LOC116407737 [nucleoplasm] (Xenopus tropicalis)
Histone H2A.x [nucleoplasm] (Mus musculus)
LOC100487067 [nucleoplasm] (Xenopus tropicalis)
h2ax1 [nucleoplasm] (Danio rerio)
zgc:56685 [nucleoplasm] (Danio rerio)
H2AX [nucleoplasm] (Canis familiaris)
H2AX [nucleoplasm] (Dictyostelium discoideum)
H2AX [nucleoplasm] (Sus scrofa)
H2Av3 [nucleoplasm] (Dictyostelium discoideum)
htas-1 [nucleoplasm] (Caenorhabditis elegans)
H2Av1 [nucleoplasm] (Dictyostelium discoideum)
LOC101732059 [nucleoplasm] (Xenopus tropicalis)
His2A:CG33859 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
OpenTargets
ENSEMBL
HPA
PRO
Pharos - Targets
GlyGen
PDB
Interactors (86)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14676 MDC1  6 0.965 21
 UniProt:O60934 NBN  3 0.859 14
 UniProt:P62805 H4C1  17 0.848 7
 UniProt:P09874 PARP1  4 0.845 12
 UniProt:P49959 MRE11  2 0.809 7
 UniProt:Q12888 TP53BP1  3 0.793 6
 UniProt:O15355 PPM1G      0.725 6
 UniProt:P38398 BRCA1  20 0.714 4
 UniProt:Q15554 TERF2  2 0.681 4
 UniProt:P58876 H2BC5  9 0.669 3
 UniProt:Q14191 WRN  2 0.667 6
 UniProt:Q9Y5B9 SUPT16H  1 0.643 5
 UniProt:Q12905 ILF2  5 0.643 3
 UniProt:Q8N108 MIER1      0.643 5
 UniProt:P46783 RPS10  2 0.643 4
 UniProt:O94880 PHF14      0.643 4
 UniProt:P55209 NP1L1      0.643 5
 UniProt:Q08945 SSRP1  1 0.643 5
 UniProt:Q16695 H3-4  3 0.641 12
 UniProt:P02545 LMNA  3 0.604 3
 UniProt:P63104 YWHAZ  2 0.577 6
 UniProt:Q6ZW49-1 PAXIP1      0.558 7
 UniProt:Q99986 VRK1  2 0.544 3
 UniProt:Q6P4T3 Q6P4T3      0.544 2
 UniProt:O15297 PPM1D  1 0.544 3
 UniProt:P51532 SMARCA4  1 0.537 9
 UniProt:Q8IUE6 H2AC21  11 0.527 3
 UniProt:Q9H9Z2 LIN28A  1 0.527 2
 UniProt:P16403 H1-2  1 0.527 2
 UniProt:P62269 RPS18  2 0.527 2
 UniProt:Q01831 XPC  5 0.527 3
 UniProt:Q9BQ69 MACD1      0.527 2
 UniProt:Q9BRT9 GINS4  1 0.527 2
 UniProt:Q9H2C0 GAN  1 0.527 3
 UniProt:Q3T8J9 GON4L      0.527 4
 UniProt:P33991 MCM4  1 0.527 4
 UniProt:P61247 RPS3A  2 0.527 2
 UniProt:P12956 XRCC6  5 0.527 2
 UniProt:Q5TEC6 H37      0.527 3
 UniProt:Q2M2E5 CE064      0.527 2
 UniProt:Q96RY5 CRML      0.527 3
 UniProt:P46782 RPS5  2 0.527 3
 UniProt:Q15527 SURF2      0.527 2
 UniProt:Q9UHA2 S18L2      0.527 4
 UniProt:Q96LZ2 MAGBA      0.527 2
 UniProt:P62979 RPS27A  20 0.527 3
 UniProt:P49736 MCM2  1 0.527 4
 UniProt:P62857 RPS28  2 0.527 2
 UniProt:Q96HA7 TONSL      0.527 4
 UniProt:P23527 H2BC17  9 0.527 3
 UniProt:P62249 RPS16  2 0.527 2
 UniProt:P62841 RPS15  2 0.527 3
 UniProt:Q9Y4C8 RBM19      0.527 3
 UniProt:P23396 RPS3  2 0.527 3
 UniProt:Q14207 NPAT      0.527 2
 UniProt:Q6PH81 CP087      0.527 3
 UniProt:Q14566 MCM6  1 0.527 2
 UniProt:P11487 FGF3  1 0.527 2
 UniProt:Q9BRX5 GINS3  1 0.527 2
 UniProt:P22492 H1T      0.527 4
 UniProt:Q96P70 IPO9      0.527 4
 UniProt:P49711 CTCF  1 0.527 3
 UniProt:Q6ZRQ5 MMS22      0.527 4
 UniProt:Q8TAQ5 ZNF420  2 0.527 2
 UniProt:P0CB38 PAB4L      0.527 2
 UniProt:Q92878 RAD50  1 0.527 3
 UniProt:Q9Y2T7 YBOX2      0.527 2
 UniProt:O43167 ZBT24      0.527 2
 UniProt:P67809 YBX1  5 0.527 4
 UniProt:P62917 RPL8  3 0.527 2
 UniProt:Q13601 KRR1  1 0.527 3
 UniProt:P15880 RPS2  3 0.527 2
 UniProt:P41208 CETN2  3 0.527 3
 UniProt:Q9Y248 GINS2  1 0.527 2
 UniProt:Q7KZ85 SUPT6H  1 0.527 3
 UniProt:P49916 LIG3  1 0.527 3
 UniProt:Q12798 CETN1  7 0.527 3
 UniProt:Q9H6F5 CCD86      0.527 3
 UniProt:P61769-PRO_0000018779 B2M      0.524 5
 UniProt:P46933-1 APBB1      0.524 2
 UniProt:P45983 MAPK8  3 0.524 3
 UniProt:P18887 XRCC1  1 0.491 3
 UniProt:Q13315 ATM  5 0.491 2
 UniProt:Q9NX02 NALP2      0.463 3
 IntAct:EBI-1265559 MYC      0.462 2
 IntAct:EBI-5276484 ACTB      0.462 2
Cite Us!