AKR1C3 reduces atRAL to atROL

Stable Identifier
R-HSA-5615668
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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AKR1C3 reduces atRAL to atROL
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The cytosolic aldo-keto reductase 1C3 (AKR1C3) can reduce all-trans-retinal (atRAL) to all-trans-retinol (atROL) (Ruiz et al. 2011). AKR1C3 functions to reduce synthesis of atRA to prevent toxic or teratogenic effects of excess atRA.
Literature References
PubMed ID Title Journal Year
21851338 Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

Ruiz, FX, Porté, S, Gallego, O, Moro, A, Ardèvol, A, Del Río-Espínola, A, Rovira, C, Farrés, J, Parés, X

Biochem. J. 2011
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Output
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as an event of
Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of AKR1C3 [cytosol]

Physical Entity
AKR1C3 [cytosol] (Homo sapiens)
Activity
all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)
Orthologous Events
AKR1C3 reduces atRAL to atROL (Bos taurus)
AKR1C3 reduces atRAL to atROL (Caenorhabditis elegans)
AKR1C3 reduces atRAL to atROL (Canis familiaris)
AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)
AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)
AKR1C3 reduces atRAL to atROL (Mus musculus)
AKR1C3 reduces atRAL to atROL (Rattus norvegicus)
AKR1C3 reduces atRAL to atROL (Saccharomyces cerevisiae)
AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)
AKR1C3 reduces atRAL to atROL (Sus scrofa)
Cross References
RHEA
Authored
Jassal, B  (2014-04-16)
Reviewed
Duester, G  (2014-07-28)
Napoli, JL  (2014-09-01)
Created
Jassal, B  (2014-07-28)
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