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Complexed PIWIL1 binds pre-piRNA
Stable Identifier
R-HSA-5615682
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Complexed PIWIL1 binds pre-piRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL1 (HIWI, homolog of MIWI in mouse), likely in a complex with other proteins such as TDRD6 and TDRKH, which interact with methylated arginine residues on PIWIL1 and are required for piRNA biogenesis. Binding by PIWIL1 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.
Literature References
PubMed ID
Title
Journal
Year
21465557
Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain
Zhou, MM
,
Yan, K
,
Zhang, Q
,
Zeng, L
Proteins
2011
Participants
Input
4xMeR-PIWIL1:TDRD6:TDRKH [cytosol]
(Homo sapiens)
pre-piRNA [cytosol]
(Homo sapiens)
Output
4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH [cytosol]
(Homo sapiens)
Participates
as an event of
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Inferred From
Complexed Piwil1 binds pre-piRNA (Mus musculus)
Authored
May, B (2014-06-14)
Reviewed
Saito, K (2014-10-25)
Created
May, B (2014-07-29)
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