B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA

Stable Identifier
R-HSA-5617143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Glycosyltransferase-like protein LARGE2 (GYLTL1B) is a bifunctional glycosyltransferases with both xylosyltransferase and beta-1,3-glucuronyltransferase activities which can form polymeric Xyl-GlcA repeats. GYLTL1B is involved in the physiological function of alpha-dystroglycan (DAG1) which plays a key role in skeletal muscle function and regeneration (Inamori et al. 2013, Wells 2013, Inamori et al. 2014).

Literature References
PubMed ID Title Journal Year
25138275 Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of ╬▒-dystroglycan in cells and tissues

Inamori, K, Willer, T, Hara, Y, Venzke, D, Anderson, ME, Clarke, NF, Guicheney, P, B├Ânnemann, CG, Moore, SA, Campbell, KP

J. Biol. Chem. 2014
23125099 Xylosyl- and glucuronyltransferase functions of LARGE in ?-dystroglycan modification are conserved in LARGE2

Inamori, K, Hara, Y, Willer, T, Anderson, ME, Zhu, Z, Yoshida-Moriguchi, T, Campbell, KP

Glycobiology 2013
23329833 The o-mannosylation pathway: glycosyltransferases and proteins implicated in congenital muscular dystrophy

Wells, L

J. Biol. Chem. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glucuronosyltransferase activity of B4GAT1:GYLTL1B [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created