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TYR [melanosome membrane]
Stable Identifier
R-HSA-5617243
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
melanosome membrane
Synonyms
Tyrosinase, TYRO_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Melanin biosynthesis (Homo sapiens)
DHI and DHICA polymerize forming eumelanin (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Dopa is oxidized to dopaquinone by TYR (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
TYR [melanosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14679 TYR
Gene Names
TYR
Chain
signal peptide:1-18, chain:19-529
Reference Genes
COSMIC (genes):TYR P146792
dbSNP Gene:7299 P146792
ENSEMBL:ENSG00000077498 TYR
Participates
as an output of
MITF-M-dependent TYR gene expression (Homo sapiens)
as a component of
TYR:2xCu2+ [melanosome membrane] (Homo sapiens)
Inferred To
TYR [melanosome membrane]
(Bos taurus)
TYR [melanosome membrane]
(Canis familiaris)
TYR [melanosome membrane]
(Dictyostelium discoideum)
TYR [melanosome membrane]
(Gallus gallus)
TYR [melanosome membrane]
(Mus musculus)
TYR [melanosome membrane]
(Sus scrofa)
tyr [melanosome membrane]
(Xenopus tropicalis)
tyr-6 [melanosome membrane]
(Caenorhabditis elegans)
Tyr [melanosome membrane]
(Rattus norvegicus)
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51810 GPR143
1
GPR143 [plasma membrane]
(R-HSA-8851292)
0.518
4
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