HOXD1 chromatin is activated

Stable Identifier
R-HSA-5617445
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from the Hoxd1 homolog in mouse embryos, HOXD1 is not expressed in hindbrain. In mouse, expression of Hoxd1 begins at E8.5 in caudal lateral mesoderm. At E9.5 to E11.5 Hoxd1 expression is observed in prosomeres p2 and p3 of the diencephalon, dermatomes, urogenital tubercle, and tail bud. Expression is inducible by retinoic acid in neuroblastoma cells, however it is unknown if the induction is direct or indirect (Manohar et al. 1996, Zha et al. 2012). Nerve Growth Factor induces Hoxd1 expression in nociceptors of mouse embryos. As inferred from human posterior HOXD genes in primary human fibroblasts (Lan et al. 2007), other anterior HOX genes, and mouse Hoxd1, the activation of HOXD1 chromatin may be associated with loss of methylation at lysine-27 of histone H3 (H3K27me3) loss of polycomb repressive complex 2 (PRC2), gain of histone acetylation, and gain of methylation at histone H3K4. Like other Hox gene clusters, the HoxD cluster in mouse changes position relative to other loci in the nucleus during activation.

Literature References
PubMed ID Title Journal Year
7501971 Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation

Manohar, CF, Salwen, HR, Furtado, MR, Cohn, SL

Tumour Biol. 1996
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Lan, F, Bayliss, PE, Rinn, JL, Whetstine, JR, Wang, JK, Chen, S, Iwase, S, Alpatov, R, Issaeva, I, Canaani, E, Roberts, TM, Chang, HY, Shi, Y

Nature 2007
22879880 Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation

Zha, Y, Ding, E, Yang, L, Mao, L, Wang, X, McCarthy, BA, Huang, S, Ding, HF

PLoS ONE 2012
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