HOXA1 mRNA is translated

Stable Identifier
R-HSA-5617458
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The HOXA1 mRNA is translated to yield HOXA1 protein (Chen et al. 2013, Chen et al. 2014). MicroRNAs miR-10a (Garzon et al. 2006), let-7c (Zhan et al. 2013), miR-99 (Chen et al. 2013) and miR-100 (Chen et al. 2014) negatively regulate translation in adult cells, however their roles in embryonic cells are unknown.

Literature References
PubMed ID Title Journal Year
24312487 MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells

Chen, D, Chen, Z, Jin, Y, Dragas, D, Zhang, L, Adjei, BS, Wang, A, Dai, Y, Zhou, X

PLoS ONE 2013
23534758 Let-7c inhibits NSCLC cell proliferation by targeting HOXA1

Zhan, M, Qu, Q, Wang, G, Liu, YZ, Tan, SL, Lou, XY, Yu, J, Zhou, HH

Asian Pac. J. Cancer Prev. 2013
16549775 MicroRNA fingerprints during human megakaryocytopoiesis

Garzon, R, Pichiorri, F, Palumbo, T, Iuliano, R, Cimmino, A, Aqeilan, RI, Volinia, S, Bhatt, D, Alder, H, Marcucci, G, Calin, GA, Liu, CG, Bloomfield, CD, Andreeff, M, Croce, CM

Proc. Natl. Acad. Sci. U.S.A. 2006
24586203 miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion

Chen, D, Sun, Y, Yuan, Y, Han, Z, Zhang, P, Zhang, J, You, MJ, Teruya-Feldstein, J, Wang, M, Gupta, S, Hung, MC, Liang, H, Ma, L

PLoS Genet. 2014
Participants
Participant Of
Inferred From
Authored
Reviewed