HOXB2 gene is transcribed

Stable Identifier
R-HSA-5617486
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HOXB2 gene is transcribed
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The HOXB2 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in carcinoma cells in Simeone et al. 1990). In mouse embryos Hoxb2 mRNA is observed in rhombomere 3 and caudally in the neural tube and mesoderm derivatives such as lung.
Literature References
PubMed ID Title Journal Year
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Russo, G, Acampora, D, Pannese, M, Faiella, A, D'Esposito, M, Zappavigna, V, Giampaolo, A, Stornaiuolo, A, Simeone, A, Carè, A

Differentiation 1989
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Acampora, D, Mavilio, F, Boncinelli, E, Arcioni, L, Andrews, PW, Simeone, A

Nature 1990
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HOXB1:PBX1:MEIS1,PKNOX1 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
HOXB1:PBX1:MEIS1,PKNOX1 [nucleoplasm]
Regulator
EGR2 at active HOXB2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Inferred From
Hoxb2 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-12)
Cite Us!