HOXB3 mRNA is translated

Stable Identifier
R-HSA-5617668
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

HOXB3 mRNA is translated to yield HOXB3 protein (Palakurthy et al. 2009, Li et al. 2012, Chen et al. 2013). Translation is repressed by the microRNAs miR-7 and miR-218 (Li et al. 2012) and miR-10A (Weiss et al. 2009).

Literature References
PubMed ID Title Journal Year
22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

Li, Q, Zhu, F, Chen, P

Biochem. Biophys. Res. Commun. 2012
19747919 Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer

Weiss, FU, Marques, IJ, Woltering, JM, Vlecken, DH, Aghdassi, A, Partecke, LI, Heidecke, CD, Lerch, MM, Bagowski, CP

Gastroenterology 2009
19854132 Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression

Palakurthy, RK, Wajapeyee, N, Santra, MK, Gazin, C, Lin, L, Gobeil, S, Green, MR

Mol. Cell 2009
23219899 HoxB3 promotes prostate cancer cell progression by transactivating CDCA3

Chen, J, Zhu, S, Jiang, N, Shang, Z, Quan, C, Niu, Y

Cancer Lett. 2013
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