HOXB3 gene is transcribed

Stable Identifier
R-HSA-5617672
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

The HOXB3 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in carcinoma cells in Simeone et al. 1990). The HOXB3 mRNA is a target of the microRNAs miR-7 and miR-218 in breast cancer cells (Li et al. 2012) and miR-10A (Weiss et al. 2009). In mouse embryos Hoxb3 mRNA is observed strongly in rhombomere 5 and more weakly in rhombomeres 6 and 7 of the hindbrain. Hoxb3 mRNA is also observed in mesodermal derivatives including lung, stomach, pancreas, and metanephros, and in neural crest derivatives.

Literature References
PubMed ID Title Journal Year
19747919 Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer

Weiss, FU, Marques, IJ, Woltering, JM, Vlecken, DH, Aghdassi, A, Partecke, LI, Heidecke, CD, Lerch, MM, Bagowski, CP

Gastroenterology 2009
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Giampaolo, A, Acampora, D, Zappavigna, V, Pannese, M, D'Esposito, M, Carč, A, Faiella, A, Stornaiuolo, A, Russo, G, Simeone, A

Differentiation 1989
22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

Li, Q, Zhu, F, Chen, P

Biochem. Biophys. Res. Commun. 2012
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Simeone, A, Acampora, D, Arcioni, L, Andrews, PW, Boncinelli, E, Mavilio, F

Nature 1990
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