BBSome binds RAB3IP

Stable Identifier
R-HSA-5617815
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The BBS1 component of the BBSome complex binds RAB3IP, a GEF for the small GTPase RAB8A. RAB3IP is required for RAB8A to localize to the cilium, and depletion of RAB3IP compromises cilia formation (Nachury et al, 2007; Loktev et al, 2008). GTP-bound RAB8A may promote ciliogenesis by promoting the traffic of post-Golgi vesicles to the base of the cilium (Nachury et al, 2007; reviewed in Zerial and McBride, 2001; Ishikawa et al, 2011; Hsiao et al, 2012; Sung and Leroux, 2013).

Literature References
PubMed ID Title Journal Year
23351793 Trafficking in and to the primary cilium

Hsiao, YC, Tuz, K, Ferland, RJ

Cilia 2012
21427764 Ciliogenesis: building the cell's antenna

Ishikawa, H, Marshall, WF

Nat. Rev. Mol. Cell Biol. 2011
24296415 The roles of evolutionarily conserved functional modules in cilia-related trafficking

Sung, CH, Leroux, MR

Nat. Cell Biol. 2013
11252952 Rab proteins as membrane organizers

Zerial, M, McBride, H

Nat. Rev. Mol. Cell Biol. 2001
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK

Cell 2007
19081074 A BBSome subunit links ciliogenesis, microtubule stability, and acetylation

Loktev, AV, Zhang, Q, Beck, JS, Searby, CC, Scheetz, TE, Bazan, JF, Slusarski, DC, Sheffield, VC, Jackson, PK, Nachury, MV

Dev. Cell 2008
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