RAB3IP stimulates nucleotide exchange on RAB8A

Stable Identifier
R-HSA-5617816
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

RAB3IP is a GEF for RAB8A, the only RAB GTPase localized in the cilium. GTP-bound RAB8A may play a role in recruiting vesicles from the Golgi to the ciliary base and is required for cilia formation (Nachury et al, 2007; Yoshimura et al, 2007; reviewed in Reiter et al, 2012).

Literature References
PubMed ID Title Journal Year
17646400 Functional dissection of Rab GTPases involved in primary cilium formation

Yoshimura, S, Egerer, J, Fuchs, E, Haas, AK, Barr, FA

J. Cell Biol. 2007
22653444 The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

Reiter, JF, Blacque, OE, Leroux, MR

EMBO Rep. 2012
17574030 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Nachury, MV, Loktev, AV, Zhang, Q, Westlake, CJ, Peränen, J, Merdes, A, Slusarski, DC, Scheller, RH, Bazan, JF, Sheffield, VC, Jackson, PK

Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rab guanyl-nucleotide exchange factor activity of basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed