TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi

Stable Identifier
Reaction [omitted]
Homo sapiens
TRAF3IP1 binds IFT20
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IFT20 is unique among IFT B components in that, in addition to being localized at the cilium and the centrosome, a pool of IFT20 exists at the Golgi in complex with the golgin protein TRIP11 (Follit et al, 2006; Follit et al, 2008; Follit et al, 2009). Independent of its interaction with TRIP11, IFT20 has been shown to interact with the IFT B complex member TRAF3IP1 at the cilium, and overexpression of TRAF3IP1 displaces IFT20 from the Golgi (Follit et al, 2009). Partial depletion of IFT20 disrupts the traffic of membrane proteins to the cilium (Follit et al, 2006; Follit et al, 2009). Taken together, these data suggest a model where TRAF3IP1 mediates recruitment of IFT20-carrying vesicles from the Golgi to the site of cilium assembly, thus completing assembly of the IFT B complex and delivering both lipid and protein cargo for cilium biogenesis (Follit et al, 2008; Follit et al, 2009; reviewed in Ishikawa et al, 2011).

Literature References
PubMed ID Title Journal Year
16775004 The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

Follit, JA, Tuft, RA, Fogarty, KE, Pazour, GJ

Mol. Biol. Cell 2006
21427764 Ciliogenesis: building the cell's antenna

Ishikawa, H, Marshall, WF

Nat. Rev. Mol. Cell Biol. 2011
19253336 Characterization of mouse IFT complex B

Follit, JA, Xu, F, Keady, BT, Pazour, GJ

Cell Motil. Cytoskeleton 2009
19112494 The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex

Follit, JA, San Agustin, JT, Xu, F, Jonassen, JA, Samtani, R, Lo, CW, Pazour, GJ

PLoS Genet. 2008
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