HOXB4 gene is transcribed

Stable Identifier
R-HSA-5617867
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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HOXB4 gene is transcribed
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The HOXB4 gene is transcribed to yield mRNA (in embryos in Giampaolo et al. 1989, in carcinoma cells in Simeone et al. 1990). The microRNA miR-23a binds the 3' untranslated region of HOXB4 mRNA (Koller et al 2013). In mouse embryos Hoxb4 mRNA is observed in rhombomere 7, paraxial mesoderm of somite 7, and caudally.
Literature References
PubMed ID Title Journal Year
2570724 Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system

Russo, G, Acampora, D, Pannese, M, Faiella, A, D'Esposito, M, Zappavigna, V, Giampaolo, A, Stornaiuolo, A, Simeone, A, Carè, A

Differentiation 1989
23630040 Identification of the transcription factor HOXB4 as a novel target of miR-23a

Guertl, B, Korbelius, M, Hoefler, G, Leuschner, I, Koller, K, Das, S

Genes Chromosomes Cancer 2013
1975088 Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Acampora, D, Mavilio, F, Boncinelli, E, Arcioni, L, Andrews, PW, Simeone, A

Nature 1990
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
NCOA3 [nucleoplasm]
EP300 [nucleoplasm]
RXRA:RARA,B:atRA [nucleoplasm]
MLL3,4 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Inferred From
Hoxb4 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-15)
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