HOXC4 chromatin is activated

Stable Identifier
R-HSA-5617887
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

As inferred from mouse embryos, HOXC4 is expressed at E12.5 caudal to rhombomere 7 (r7) and at the level of prevertebrae 4-5 and caudally. In carcinoma cells treated with retinoic acid (Lee et al. 2007) and primary fibroblasts (Lan et al. 2007) chromatin at HOXC4 loses methylation at lysine-27 of histone H3 (H3K27me3), loses polycomb repressive complex 2 (PRC2), and gains methylation at lysine-4 of histone H3 (H3K4me3). In embryonal carcinoma cells KDM6A (UTX) binds HOXC4 and participates in demethylating H3K27 at HOXC4 (Lee et al. 2007)

Literature References
PubMed ID Title Journal Year
17761849 Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Lee, MG, Villa, R, Trojer, P, Norman, J, Yan, KP, Reinberg, D, Di Croce, L, Shiekhattar, R

Science 2007
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Lan, F, Bayliss, PE, Rinn, JL, Whetstine, JR, Wang, JK, Chen, S, Iwase, S, Alpatov, R, Issaeva, I, Canaani, E, Roberts, TM, Chang, HY, Shi, Y

Nature 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity (H3-K27 specific) of MLL2,3 complex [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created