Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FKBP4 [cytosol]
Stable Identifier
R-HSA-5618108
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FKBP52, Peptidyl-prolyl cis-trans isomerase FKBP4, Immunophilin FKBP52
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
AR binds AR agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
AR binds AR antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C1 binds NR3C1 agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C2 binds NR3C2 antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C2:NR3C2 antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C2 binds fludrocortisone (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C2:fludrocortisone [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
PGR binds PGR agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
PGR:PGR agonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
PGR binds PGR antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
PGR:PGR antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
NR3C1 binds NR3C1 agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
FKBP4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02790 FKBP4
Gene Names
FKBP4, FKBP52
Chain
chain:1-459, initiator methionine:, chain:2-459
Reference Genes
BioGPS Gene:2288 FKBP4
COSMIC (genes):FKBP4 FKBP4
CTD Gene:2288 FKBP4
dbSNP Gene:2288 FKBP4
ENSEMBL:ENSG00000004478 FKBP4
ENSEMBL_homo_sapiens_GENE:ENSG00000004478.8 FKBP4
HGNC:3720 FKBP4
KEGG Gene (Homo sapiens):2288 FKBP4
Monarch:2288 FKBP4
NCBI Gene:2288 FKBP4
OMIM:600611 FKBP4
UCSC:Q02790 FKBP4
Reference Transcript
RefSeq:NM_002014.3 FKBP4
Other Identifiers
11736021_a_at
11736022_at
11744683_s_at
1560303_PM_at
1560303_at
1560305_PM_x_at
1560305_x_at
16746808
200894_PM_s_at
200894_s_at
200895_PM_s_at
200895_s_at
2288
3171319
3171330
3171664
3401100
3401101
3401104
3401105
3401106
3401108
3401109
3401110
3401111
3401112
3401113
3401114
3401116
3401117
3401118
3401120
3401121
3401122
3401123
3401124
38729_at
4051399
7953100
A_23_P128372
A_32_P71788
GE58127
GE82381
GO:0003723
GO:0003755
GO:0003824
GO:0005515
GO:0005524
GO:0005525
GO:0005528
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005874
GO:0006457
GO:0006463
GO:0006825
GO:0007010
GO:0007566
GO:0008092
GO:0010977
GO:0016853
GO:0022414
GO:0023052
GO:0030154
GO:0030424
GO:0030521
GO:0030674
GO:0030850
GO:0031072
GO:0031111
GO:0031115
GO:0031503
GO:0032767
GO:0032991
GO:0035259
GO:0042995
GO:0043025
GO:0043226
GO:0044295
GO:0046661
GO:0048156
GO:0048471
GO:0048608
GO:0048856
GO:0051219
GO:0060090
GO:0061077
GO:0065003
GO:0070062
GO:0140096
HMNXSV003021650
Hs.848.0.A1_3p_a_at
Hs2.407281.1.S1_3p_s_at
ILMN_1782045
M88279_at
PH_hs_0000103
TC12000028.hg
g4503728_3p_a_at
Participates
as a component of
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 ligands [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C1 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:Androgens [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR:AR antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:AR [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
as an input of
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
Other forms of this molecule
FKBP4 [nucleoplasm]
FKBP4 [nucleoplasm]
Inferred To
Fkbp59 [cytosol]
(Drosophila melanogaster)
Fkbp4 [cytosol]
(Mus musculus)
Fkbp4 [cytosol]
(Rattus norvegicus)
FKBP35 [cytosol]
(Plasmodium falciparum)
Ghost homologue of FKBP4 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of FKBP4 [cytosol]
(Danio rerio)
Ghost homologue of FKBP4 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of FKBP4 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of FKBP4 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of FKBP4 [cytosol]
(Xenopus tropicalis)
FKBP4 [cytosol]
(Bos taurus)
FKBP4 [cytosol]
(Canis familiaris)
FKBP4 [cytosol]
(Gallus gallus)
FKBP4 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_002005.1
ZINC - World Drugs
FKBP4_HUMAN
Guide to Pharmacology - Targets
3176
OpenTargets
ENSG00000004478
ZINC - Substances
FKBP4_HUMAN
ZINC target
Q02790
PRO
Q02790
PDB
1QZ2
,
1N1A
,
4LAV
,
4LAW
,
4DRJ
,
1Q1C
,
6RCY
,
4LAY
,
1P5Q
,
8FFV
,
4TW8
,
4LAX
GeneCards
Q02790
HPA
ENSG00000004478-FKBP4
Ensembl
ENSP00000001008
,
ENST00000001008
,
ENSG00000004478
Pharos - Targets
Q02790
ZINC - Predictions - Purchasable
FKBP4_HUMAN
HMDB Protein
HMDBP10689
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.793
6
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.784
9
UniProt:P35467
1
S100A1 [extracellular region]
(R-RNO-6805991)
0.753
7
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.742
5
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.629
7
UniProt:P29034 S10A2
0.591
3
UniProt:P06703 S10A6
0.591
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
2
UniProt:Q8NG41 NPB
2
NPB(25-48) [extracellular region]
(R-HSA-374794)
NPB(25-53) [extracellular region]
(R-HSA-374790)
0.527
2
UniProt:Q58FG0 HS905
0.527
2
UniProt:Q58FF6 H90B4
0.527
2
UniProt:Q9BQP7 MGME1
0.527
2
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.508
2
UniProt:Q9UKV8 AGO2
2
AGO2 [nucleoplasm]
(R-HSA-5578701)
AGO2 [cytosol]
(R-HSA-209723)
0.499
2
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.499
3
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text