Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Stable Identifier
R-HSA-5619107
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The nuclear pore complex (NPC) trafficks cargo across the nuclear membrane. Nucleoprotein TPR functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. The complex glucokinase (GCK1) and glucokinase regulatory protein (GKRP) can be translocated to the nucleus via the NPC. Defects in TPR may confer susceptibility towards thyroid papillary carcinona (TPC; MIM:18850), a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue (Vriens et al. 2009, Bonora et al. 2010).

Literature References
PubMed ID Title Journal Year
20001717 Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancer

Vriens, MR, Suh, I, Moses, W, Kebebew, E

Thyroid 2009
20628519 Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies

Bonora, E, Tallini, G, Romeo, G

J Oncol 2010
Participants
Participant Of
Disease
Name Identifier Synonyms
papillary carcinoma 3113 Papillary carcinoma (morphologic abnormality), Papillary carcinoma, Papillary carcinoma NOS (morphologic abnormality)
Authored
Reviewed
Created