VxPx cargo-targeting to cilium

Stable Identifier
R-HSA-5620916
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

A number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of these cargo to the cilium (Mazelova et al, 2009; Geng et al, 2006; Jenkins et al, 2006; Ward et al, 2011; reviewed in Deretic, 2013). Although there is some support for the presence of a VxPx or related motif in the C-terminal tail of cargo destined for ARF4-mediated transport to the cilium, the details of this have not been definitively established and other ciliary targeting sequences have also been identified (reviewed in Deretic, 2013; Bhogaraju et al, 2013).

Literature References
PubMed ID Title Journal Year
16537653 Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif

Geng, L, Okuhara, D, Yu, Z, Tian, X, Cai, Y, Shibazaki, S, Somlo, S

J. Cell. Sci. 2006
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D

EMBO J. 2009
23945166 Intraflagellar transport complex structure and cargo interactions

Bhogaraju, S, Engel, BD, Lorentzen, E

Cilia 2013
16782012 Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17

Jenkins, PM, Hurd, TW, Zhang, L, McEwen, DP, Brown, RL, Margolis, B, Verhey, KJ, Martens, JR

Curr. Biol. 2006
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
21775626 A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

Ward, HH, Brown-Glaberman, U, Wang, J, Morita, Y, Alper, SL, Bedrick, EJ, Gattone, VH, Deretic, D, Wandinger-Ness, A

Mol. Biol. Cell 2011
Participants
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