ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

Stable Identifier
R-HSA-5620921
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Recruitment of ASAP1 to the TGN facilitates the subsequent recruitment of both RAB11A and the RAB11 effector protein FIP3 to the ciliary targeting complex. RAB11FIP3 functions as a homodimer and can bind simultaneously to RAB11 and ARF4 through its C-terminal region (Inoue et al, 2008; Mazelova et al, 2009; Wang et al, 2012; Shiba et al, 2006; Eathiraj et al, 2006; Schonteich et al, 2007). RAB11FIP3 also interacts with the BAR domain of ASAP1 and in this way may play a role in stimulating the ARF GAP activity of ASAP1, promoting the inactivation ARF4 and its subsequent dissociation from the TGN (Inoue et al, 2008; reviewed in Deretic, 2013).

Literature References
PubMed ID Title Journal Year
17030804 Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1

Shiba, T, Koga, H, Shin, HW, Kawasaki, M, Kato, R, Nakayama, K, Wakatsuki, S

Proc. Natl. Acad. Sci. U.S.A. 2006
17628206 Molecular characterization of Rab11-FIP3 binding to ARF GTPases

Schonteich, E, Pilli, M, Simon, GC, Matern, HT, Junutula, JR, Sentz, D, Holmes, RK, Prekeris, R

Eur. J. Cell Biol. 2007
17007872 Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes

Eathiraj, S, Mishra, A, Prekeris, R, Lambright, DG

J. Mol. Biol. 2006
18685082 Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome

Inoue, H, Ha, VL, Prekeris, R, Randazzo, PA

Mol. Biol. Cell 2008
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D

EMBO J. 2009
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Wang, J, Morita, Y, Mazelova, J, Deretic, D

EMBO J. 2012
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
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