HOXB1 activates HOXA2 expression

Stable Identifier
R-HSA-5621010
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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As inferred from mouse homologs, HOXA2 expression is driven by HOXB1 in rhombomere 4 (r4) and EGR2 (KROX20) in r3 and r5. HOXB1 together with PBX and PREP/MEIS cofactors bind an element in the intron of HOXA2. (HOXA2 is the only HOX gene active in r2. An unknown activator, possibly a transcription factor of the SOX family, may be involved in expression in r2.)

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