Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
CLEC6A binds alpha-mannan in fungal cell walls
Stable Identifier
R-HSA-5621352
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
Dectin-2 family (Homo sapiens)
CLEC6A binds alpha-mannan in fungal cell walls (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CLEC6A (C-type lectin domain family 6 member A/Dectin-2 (Dendritic cell-associated C-type lectin 2)) a C-type lectin expressed by dendritic cells (DCs) and activated macrophages has been shown to bind structures with high mannose content (McGreal et al. 2006). It is reported to recognise a variety of pathogens including Candida albicans, Saccharomyces cerevisiae, Mycobacterium tuberculosis, Paracoccidioides brasiliensis, Histoplasma capsulatum, Aspergillus fumigatus, non-encapsulated Cryptococcus neoformans, Microsporum audouinii, Trichophyton rubrum, Schistosoma mansoni and house dust mite allergens (Sato et al. 2006, Gorjestani et al. 2011, Ritter et al. 2010, McGreal et al. 2006, Kerscher et al. 2013).
Like other members of the Dectin-2 family, cytoplasmic region of CLEC6A has no obvious signalling motif and it associates with transmembrane adapter FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) to transduce a CLEC6A/Dectin-2 signalling.
Participants
Input
alpha-mannan [plasma membrane]
CLEC6A:FCER1G dimer [plasma membrane]
(Homo sapiens)
Output
CLEC6A:FCER1G dimer:alpha-mannan [plasma membrane]
(Homo sapiens)
Participates
as an event of
Dectin-2 family (Homo sapiens)
Inferred From
Clec6a binds alpha-mannan in fungal cell walls (Mus musculus)
Authored
Garapati, P V (2014-08-29)
Reviewed
Geijtenbeek, TB (2014-09-02)
Created
Garapati, P V (2014-08-29)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text