Reactome | SYK binds to p-Y65,Y76-FCER1G

SYK binds to p-Y65,Y76-FCER1G

Stable Identifier

R-HSA-5621366

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SYK is a cytoplasmic tyrosine kinase related to ZAP70 that is expressed in all hematopoietic cells and coimmunoprecipitates with the gamma chain associated with FCGRIIIA in macrophages and with FCERI in mast cells. Tyrosine phosphorylation of the FCER1G ITAM recruits SYK and initiates a signaling cascade, leading to the activation of transcription factors such as NF-kB via CARD9-BCL10-MALT1 (Kerscher et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
17050534	Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses Yang, XL, Underhill, D, Kimberly, RP, Chung, JS, Sato, K, Luby-Phelps, K, Ariizumi, K, Cruz, PD, Wu, J, Yudate, T	J. Biol. Chem.	2006
18776906	Mincle is an ITAM-coupled activating receptor that senses damaged cells Sakuma, M, Ogata, K, Hara, H, Saito, T, Yamasaki, S, Ishikawa, E	Nat. Immunol.	2008