CD209 activate GTPase RAS

Stable Identifier
R-HSA-5621573
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Both CLEC7A (Dectin-1) and CD209 (DC-SIGN) modulates Toll-like receptor signalling by activating RAF1 which in turn induces the phosphorylation of p65 (RELA) subunit leading to the modification of p50/p65 NF-kB dimer (Gringhuis et al. 2007 & 2009). Gringhuis et al. demonstrated that CD209 (DC-SIGN) stimulated by ManLAM (lipoarabinomannan) activates the small GTPase RAS. Immunoblotting detected active RAS in dendritic cells when induced by ManLAM (Gringhuis et al. 2007). RAF1 is recruited to the membrane through an interaction with the active form of RAS.

Literature References
PubMed ID Title Journal Year
17462920 C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB

Gringhuis, SI, den Dunnen, J, Litjens, M, van Het Hof, B, van Kooyk, Y, Geijtenbeek, TB

Immunity 2007
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