Reactome | ARL6:GTP and the BBSome target cargo to the primary cilium

ARL6:GTP and the BBSome target cargo to the primary cilium

Stable Identifier

R-HSA-5624127

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

ciliary membrane

ReviewStatus

5/5

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ARL6:GTP and the BBSome target cargo to the primary cilium

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ARL6:GTP and the BBSome complex are required for the ciliary accumulation of proteins such as SSTR3, MHRC1 and SMO (Zhang et al, 2011; Jin et al, 2010; Seo et al, 2011; reviewed in Nachury et al, 2010; Sung and Leroux, 2013). BBSome localization to the primary cilium is negatively regulated by LZTFL1, and ciliary accumulation of some BBSome cargo is increased by LZTFL1 depletion (Seo et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
20603001	The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia Aguiar, M, Shida, T, Jin, H, Gygi, SP, Nachury, MV, White, SR, Schulz, S, Bazan, JF	Cell	2010
22139371	Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes Seo, S, Rahmouni, K, Bugge, K, Vogel, T, Morgan, DA, Stone, EM, Zhang, Q, Sheffield, VC, Nishimura, D, Searby, C	Proc. Natl. Acad. Sci. U.S.A.	2011
22072986	A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened Seo, S, Searby, CC, Bugge, K, Zhang, Q, Sheffield, VC, Nachury, MV, Breslow, DK	PLoS Genet.	2011
24296415	The roles of evolutionarily conserved functional modules in cilia-related trafficking Sung, CH, Leroux, MR	Nat. Cell Biol.	2013
19575670	Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Seeley, ES, Jin, H, Nachury, MV	Annu. Rev. Cell Dev. Biol.	2010