Reactome | LZTFL1 binds the BBSome and prevents its traffic to the cilium

LZTFL1 binds the BBSome and prevents its traffic to the cilium

Stable Identifier

R-HSA-5624129

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LZTFL1 binds the BBSome and prevents its traffic to the cilium

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LZTFL1 was identified as a tumor suppressor and as a protein that interacts with components of the BBSome (Wei et al, 2010; Seo et al, 2011). LZTFL1 forms cytosolic complexes with the BBSome and negatively regulates its entry into the cilium without affecting the assembly or stability of the BBSome complex. Both the BBSome and LZTFL1 have been shown to regulate the localization of the Hh signaling protein SMO (Seo et al, 2011). A recent study suggests that LZTFL1 may additionally play a role in coordinating the interaction between the BBSome and the IFT B component IFT27 and in this way contribute to the traffic of Hh pathway proteins into and out of the cilium (Eguether et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
22072986	A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened Seo, S, Searby, CC, Bugge, K, Zhang, Q, Sheffield, VC, Nachury, MV, Breslow, DK	PLoS Genet.	2011
25446516	IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment Pazour, GJ, San Agustin, JT, Keady, BT, Johnson, CA, Tobita, K, Francis, R, Liang, Y, Jonassen, JA, Eguether, T, Lo, CW, Abdelhamed, Z A, Liang, Y	Dev.Cell	2014
20233871	Tumor-suppressive functions of leucine zipper transcription factor-like 1 Cao, J, Wang, L, Zhou, W, Gao, B, Wang, W, Liu, ZP, Wei, Q	Cancer Res.	2010