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SAMHD1 [nucleoplasm]
Stable Identifier
R-HSA-5624198
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, SAMH1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P58753
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
SAMHD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3Z3 SAMHD1
Gene Names
SAMHD1, MOP5
Chain
chain:1-626
Reference Genes
BioGPS Gene:25939 SAMHD1
COSMIC (genes):SAMHD1 SAMHD1
CTD Gene:25939 SAMHD1
dbSNP Gene:25939 SAMHD1
ENSEMBL:ENSG00000101347 SAMHD1
ENSEMBL_homo_sapiens_GENE:ENSG00000101347.11 SAMHD1
HGNC:15925 SAMHD1
KEGG Gene (Homo sapiens):25939 SAMHD1
Monarch:25939 SAMHD1
NCBI Gene:25939 SAMHD1
OMIM:606754 SAMHD1
UCSC:Q9Y3Z3 SAMHD1
Reference Transcript
RefSeq:XM_005260384.3 SAMHD1
RefSeq:NM_015474.3 SAMHD1
Other Identifiers
11739148_a_at
11739149_a_at
11748841_a_at
11749510_a_at
1559883_PM_s_at
1559883_s_at
16919022
204502_PM_at
204502_at
234987_PM_at
234987_at
235529_PM_x_at
235529_x_at
235964_PM_x_at
235964_x_at
25939
34714_at
3904692
3904693
3904694
3904695
3904704
3904705
3904706
3904707
3904709
3904710
3904711
3904714
3904717
3904718
3904720
3904722
3904723
3904725
3904728
3904729
3904730
3904731
3904732
44583_at
61839_at
8066117
A_24_P267592
A_33_P3406281
GE58609
GO:0000166
GO:0000724
GO:0002376
GO:0003676
GO:0003677
GO:0003697
GO:0003723
GO:0003824
GO:0004540
GO:0005515
GO:0005525
GO:0005634
GO:0005654
GO:0005694
GO:0005886
GO:0006203
GO:0006260
GO:0006281
GO:0006310
GO:0006955
GO:0006974
GO:0008152
GO:0008270
GO:0008832
GO:0009264
GO:0016446
GO:0016787
GO:0016793
GO:0023052
GO:0032567
GO:0035861
GO:0042802
GO:0043226
GO:0045087
GO:0045088
GO:0046061
GO:0046872
GO:0048856
GO:0051289
GO:0051607
GO:0055086
GO:0060339
GO:0065003
GO:0097197
GO:0098542
GO:0106375
GO:0110025
GO:0140098
GO:1901135
HMNXSV003044373
Hs.293684.1.A1_3p_at
Hs.293684.2.S1_3p_a_at
ILMN_1721026
PH_hs_0029905
TC20000821.hg
g7661593_3p_at
Participates
as an output of
Expression of IFN-induced genes (Homo sapiens)
as a component of
SAMHD1:Zn2+ tetramer [nucleoplasm] (Homo sapiens)
Inferred To
samhd1 [nucleoplasm]
(Xenopus tropicalis)
fal [nucleoplasm]
(Drosophila melanogaster)
SAMHD1 [nucleoplasm]
(Bos taurus)
SAMHD1 [nucleoplasm]
(Caenorhabditis elegans)
SAMHD1 [nucleoplasm]
(Canis familiaris)
SAMHD1 [nucleoplasm]
(Danio rerio)
SAMHD1 [nucleoplasm]
(Dictyostelium discoideum)
SAMHD1 [nucleoplasm]
(Gallus gallus)
SAMHD1 [nucleoplasm]
(Mus musculus)
SAMHD1 [nucleoplasm]
(Plasmodium falciparum)
SAMHD1 [nucleoplasm]
(Sus scrofa)
Samhd1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_056289.2
,
XP_005260441.1
OpenTargets
ENSG00000101347
GeneCards
Q9Y3Z3
HPA
ENSG00000101347-SAMHD1
Ensembl
ENST00000682773
,
ENSP00000507178
,
ENST00000646869
,
ENSP00000262878
,
ENST00000683766
,
ENSP00000495432
,
ENST00000646673
,
ENSG00000101347
,
ENST00000646066
,
ENSP00000493810
,
ENSP00000493536
,
ENST00000644250
,
ENSP00000495667
,
ENST00000262878
,
ENSP00000506877
PRO
Q9Y3Z3
Pharos - Targets
Q9Y3Z3
Orphanet
18469
PDB
6DW7
,
4TO1
,
4RXR
,
6TX0
,
5AO3
,
4TNZ
,
7LU5
,
4ZWG
,
5AO1
,
4TNY
,
6U6Z
,
8D94
,
4RXQ
,
6YOM
,
4QFZ
,
4ZWE
,
6CM2
,
6DW3
,
7LTT
,
4RXO
,
4QFY
,
4QG1
,
7S2Y
,
6U6X
,
6DWK
,
4BZC
,
8GB1
,
4BZB
,
4TO5
,
6TXC
,
8D9J
,
3U1N
,
6DWD
,
4TO3
,
6TXA
,
7UJN
,
4TO2
,
4Q7H
,
5AO4
,
4QG4
,
4QG2
,
6DW5
,
2E8O
,
5AO2
,
4TO0
,
4QFX
,
4RXP
,
4QG0
,
5AO0
,
6DW4
,
6U6Y
,
4TNX
,
7A5Y
,
4TNR
,
6TXF
,
4MZ7
,
6TXE
,
4TO6
,
6DWJ
,
4TNQ
,
8GB2
,
4TNP
,
6XU1
,
4CC9
,
4TO4
,
4RXS
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.76
7
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
11
UniProt:Q9Y4B6 VPRBP
1
VPRBP [cytosol]
(R-HSA-975984)
0.544
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.499
2
UniProt:Q08380 LGALS3BP
2
LGALS3BP [extracellular region]
(R-HSA-8848882)
LGALS3BP [platelet dense granule lumen]
(R-HSA-8848916)
0.499
2
IntAct:EBI-15928529 VPX
0.462
2
UniProt:O75923 DYSF
1
DYSF [cytoplasmic vesicle membrane]
(R-HSA-5263626)
0.454
2
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