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PML [cytosol]
Stable Identifier
R-HSA-5624327
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein PML, PML_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
IFNG induced TRIMs [cytosol] (Homo sapiens)
PML [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29590 PML
Gene Names
PML, MYL, PP8675, RNF71, TRIM19
Chain
chain:1-882
Reference Genes
BioGPS Gene:5371 PML
COSMIC (genes):PML PML
CTD Gene:5371 PML
dbSNP Gene:5371 PML
ENSEMBL:ENSG00000140464 PML
ENSEMBL:ENSG00000140464.20 PML
HGNC:9113 PML
KEGG Gene (Homo sapiens):5371 PML
Monarch:5371 PML
NCBI Gene:5371 PML
OMIM:102578 PML
UCSC:P29590 PML
Reference Transcript
RefSeq:NM_033238.2 PML
RefSeq:NM_033239.2 PML
RefSeq:NM_033240.2 PML
RefSeq:NM_033249.2 PML
RefSeq:NM_033250.2 PML
RefSeq:NM_033244.3 PML
RefSeq:NM_033246.2 PML
RefSeq:NM_033247.2 PML
RefSeq:NM_002675.3 PML
Other Identifiers
11726875_a_at
11726876_a_at
11728557_s_at
11729443_a_at
11741878_a_at
11741879_x_at
11745905_a_at
11751121_a_at
11751251_a_at
16802918
16802939
206503_PM_x_at
206503_x_at
210362_PM_x_at
210362_x_at
211012_PM_s_at
211012_s_at
211013_PM_x_at
211013_x_at
211014_PM_s_at
211014_s_at
211588_PM_s_at
211588_s_at
239582_PM_at
239582_at
3601388
3601389
3601390
3601393
3601394
3601395
3601401
3601403
3601410
3601412
3601413
3601414
3601415
3601416
3601417
3601418
3601419
3601420
3601421
3601422
3601423
3601424
3601425
3601426
3601427
3601428
3601436
3601437
3601438
3601439
3601441
3601442
3601443
3601445
3601447
3601449
3601450
3601451
38787_at
38788_at
5371
566_at
567_s_at
7984779
A_14_P130961
A_21_P0008833
A_23_P306148
A_23_P334664
A_23_P358944
A_24_P133542
A_24_P198598
A_24_P207139
GE515151
GE58085
GO:0000278
GO:0000781
GO:0000792
GO:0001666
GO:0002230
GO:0002376
GO:0003677
GO:0003713
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005829
GO:0006281
GO:0006351
GO:0006355
GO:0006605
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0006919
GO:0006977
GO:0007155
GO:0007179
GO:0007182
GO:0008270
GO:0008285
GO:0008630
GO:0008631
GO:0009411
GO:0010332
GO:0010522
GO:0010761
GO:0012501
GO:0016020
GO:0016363
GO:0016525
GO:0016605
GO:0016740
GO:0016925
GO:0019789
GO:0023052
GO:0030099
GO:0030154
GO:0030155
GO:0030163
GO:0030308
GO:0030578
GO:0031065
GO:0031410
GO:0031503
GO:0031625
GO:0031901
GO:0032183
GO:0032200
GO:0032206
GO:0032211
GO:0032469
GO:0032691
GO:0032692
GO:0032922
GO:0032938
GO:0034097
GO:0036211
GO:0042752
GO:0042771
GO:0042802
GO:0042803
GO:0043153
GO:0043161
GO:0043226
GO:0044790
GO:0045087
GO:0045165
GO:0045892
GO:0045893
GO:0046332
GO:0046872
GO:0048146
GO:0048384
GO:0048511
GO:0048856
GO:0048870
GO:0050821
GO:0050897
GO:0051457
GO:0051607
GO:0051726
GO:0051974
GO:0055065
GO:0055085
GO:0060058
GO:0060444
GO:0061659
GO:0065003
GO:0070059
GO:0071353
GO:0072332
GO:0090398
GO:0090402
GO:0097191
GO:0098542
GO:0140037
GO:0140096
GO:0140110
GO:1901798
GO:1904816
GO:1990830
GO:2000059
GO:2000758
GO:2000779
GO:2001235
GO:2001238
HMNXSV003003061
HMNXSV003024547
HMNXSV003051703
HMNXSV003054775
Hs.258217.0.A1_3p_at
ILMN_1731299
ILMN_1750861
ILMN_1811588
ILMN_2248192
ILMN_2398378
M79462_at
M79463_s_at
PH_hs_0005007
TC15000671.hg
TC15002275.hg
TC15002276.hg
X63131_s_at
g12275906_3p_s_at
g12275908_3p_s_at
g190116_3p_at
g4505902_3p_a_at
p19791
Participates
as a member of
IFNG induced TRIMs [cytosol] (Homo sapiens)
Other forms of this molecule
polySUMO3-K65,K160,K490-PML [nucleoplasm]
polySUMO2-K65,K160,K490-PML [nucleoplasm]
monoSUMO1-K65,160,490-PML [nucleoplasm]
PML [nucleoplasm]
Cross References
RefSeq
NP_150252.1
,
NP_150243.2
,
NP_150253.2
,
NP_150242.1
,
NP_150249.1
,
NP_002666.1
,
NP_150250.2
,
NP_150247.2
,
NP_150241.2
OpenTargets
ENSG00000140464
HPA
ENSG00000140464-PML
GeneCards
P29590
Ensembl
ENST00000569477
,
ENSP00000455612
,
ENST00000354026
,
ENST00000565898
,
ENSP00000457023
,
ENSP00000315434
,
ENST00000564428
,
ENST00000395135
,
ENST00000395132
,
ENSP00000268058
,
ENSP00000455838
,
ENSG00000140464
,
ENSP00000394642
,
ENSP00000378567
,
ENSP00000378564
,
ENST00000435786
,
ENST00000567543
,
ENSP00000353004
,
ENSP00000395576
,
ENSP00000456277
,
ENST00000359928
,
ENST00000436891
,
ENSP00000268059
,
ENSP00000456486
,
ENST00000268058
,
ENST00000268059
,
ENST00000569965
PRO
P29590
Pharos - Targets
P29590
Orphanet
15112
PDB
6UYT
,
6UYQ
,
1BOR
,
4WJO
,
6IMQ
,
2MVW
,
8DJI
,
6UYV
,
6UYS
,
5YUF
,
8DJH
,
6UYP
,
6UYU
,
6UYO
,
6UYR
,
2MWX
,
4WJN
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.832
6
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.791
6
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.744
9
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.7
4
UniProt:P03243-1
0.621
3
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.611
7
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.609
6
UniProt:Q13164 MAPK7
4
MAPK7 [nucleoplasm]
(R-HSA-199961)
MAPK7 [cytosol]
(R-HSA-198754)
p-T218,Y221-MAPK7 [cytosol]
(R-HSA-198721)
p-T218,Y221-MAPK7 [nucleoplasm]
(R-HSA-198738)
0.571
6
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.556
3
UniProt:Q8UN00 Q8UN00
0.556
4
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.553
2
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.524
4
UniProt:P25788 PSMA3
2
PSMA3 [nucleoplasm]
(R-HSA-174323)
PSMA3 [cytosol]
(R-HSA-68728)
0.508
2
UniProt:P03255-1
0.463
2
UniProt:O15055 PER2
4
Ub-p-S-PER2 [cytosol]
(R-HSA-517835)
PER2 [cytosol]
(R-HSA-400399)
p-S-PER2 [nucleoplasm]
(R-HSA-3325591)
p-S-PER2 [cytosol]
(R-HSA-400331)
0.463
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.463
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 [cytosol]
(R-HSA-195249)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
0.463
2
UniProt:P27958-PRO_0000037566
0.463
6
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.463
2
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