RAF1 binds p21 RAS:GTP

Stable Identifier
R-HSA-5624494
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 translocates to the membrane through interaction with the active form of RAS. This interaction induces a conformational change in RAF1 and is required for RAF1 activation (Gringhuis et al. 2007, Wellbrock et al. 2004).

Literature References
PubMed ID Title Journal Year
7517401 Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner

Cleghon, V, Morrison, DK

J Biol Chem 1994
15520807 The RAF proteins take centre stage

Wellbrock, C, Karasarides, M, Marais, R

Nat Rev Mol Cell Biol 2004
17462920 C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB

Gringhuis, SI, den Dunnen, J, Litjens, M, van Het Hof, B, van Kooyk, Y, Geijtenbeek, TB

Immunity 2007
Participants
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Orthologous Events
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Created