Reactome | DYNLL1 [cilium]

DYNLL1 [cilium]

Stable Identifier

R-HSA-5624863

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

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External Reference Information

External Reference

UniProt:P63167 DYNLL1

Gene Names

DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1

Chain

chain:1-89

Reference Genes

BioGPS Gene:8655 DYNLL1

COSMIC (genes):DYNLL1 DYNLL1

CTD Gene:8655 DYNLL1

dbSNP Gene:8655 DYNLL1

ENSEMBL:ENSG00000088986.11 DYNLL1

HGNC:15476 DYNLL1

KEGG Gene (Homo sapiens):8655 DYNLL1

Monarch:8655 DYNLL1

NCBI Gene:8655 DYNLL1

OMIM:601562 DYNLL1

Reference Transcript

Other Identifiers

0005900731

11753833_a_at

200703_PM_at

200703_at

3059785

3434394

3434396

3434398

3434402

3434403

3434404

3434407

3434408

3434409

3434410

34891_at

3574114

3574116

7959164

7980535

8655

A_23_P65031

A_24_P124672

GE61176

GO:0000776

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0006915

GO:0007017

GO:0008150

GO:0008180

GO:0012501

GO:0015630

GO:0016020

GO:0021762

GO:0030286

GO:0031410

GO:0032991

GO:0042326

GO:0043226

GO:0044782

GO:0045505

GO:0048856

GO:0051959

GO:0060271

GO:0070821

GO:0072686

GO:0097542

GO:0101003

HMNXSV003054414

ILMN_2300186

PH_hs_0035324

U32944_at

g4505812_3p_at

Participates

as a member of

dynein-2 light chains [cilium] (Homo sapiens)

Other forms of this molecule

DYNLL1 [cytosol]

DYNLL1 [plasma membrane]

DYNLL1 [ficolin-1-rich granule membrane]

DYNLL1 [tertiary granule membrane]

DYNLL1 [ciliary tip]

Inferred To

Homologues of DYNLL1 [cilium] (Caenorhabditis elegans)

dlc-5 [cilium] (Caenorhabditis elegans)

dynll2 [cilium] (Danio rerio)

dlc-3 [cilium] (Caenorhabditis elegans)

Dynll1 [cilium] (Mus musculus)

Dynll1 [cilium] (Rattus norvegicus)

dlc-1 [cilium] (Caenorhabditis elegans)

dlc-4 [cilium] (Caenorhabditis elegans)

dlc-6 [cilium] (Caenorhabditis elegans)

DYNLL1 [cilium] (Bos taurus)

DYNLL1 [cilium] (Canis familiaris)

DYNLL1 [cilium] (Gallus gallus)

DYNLL1 [cilium] (Sus scrofa)

dlc-2 [cilium] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001032584.1, NP_003737.1, NP_001032583.1

OpenTargets

ENSG00000088986

GeneCards

P63167

HPA

ENSG00000088986-DYNLL1

Ensembl

ENSP00000446614, ENSP00000376297, ENSP00000447907, ENST00000392509, ENST00000392508, ENST00000242577, ENST00000549989, ENSP00000376296, ENST00000548342, ENSP00000242577, ENSG00000088986

PRO

P63167

Pharos - Targets

P63167

HMDB Protein

HMDBP10685

PDB

6GZL, 3ZKF, 3ZKE, 6RLB, 6SC2, 6GZJ, 7D35, 1CMI

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	6	Active PAK1 [cytosol] (R-HSA-8964622) p-S144-PAK1 [cytosol] (R-HSA-451339) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.632	6
UniProt:O96015 DNAL4	1	DNAL4 [plasma membrane] (R-HSA-177484)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.527	2
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.508	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.508	2
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.508	2
UniProt:Q9C0C7 AMBRA1	2	AMBRA1 [cytosol] (R-HSA-1632831) p-AMBRA1 [cytosol] (R-HSA-1632854)	0.508	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2

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