Reactome | Anterograde IFT

Anterograde IFT

Stable Identifier

R-HSA-5625416

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cilium

Synonyms

Anterograde IFT trains translocate from the ciliary base to the ciliary tip

ReviewStatus

5/5

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Anterograde trains travel along the axoneme of the cilium at an estimated rate of 2 micrometers per second in an ATP- and kinesin-2-dependent fashion (reviewed in Cole and Snell, 2009). Although the particulars of IFT train-cargo interactions have not been fully elaborated, recent studies in C. reinhardtii and human cells have shown that the IFT B components IFT74 and IFT81 have tubulin-binding sites, while IFT46 is required for the ciliary transport of the outer dynein arm, and more recently, TTC26 has been shown to be required for the transport of motility-related proteins into the flagella (Bhogaraju et al, 2013; Ahmed et al, 2008; Hou et al, 2007; Ishikawa et al, 2014; reviewed in Bhogarju et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
17312020	Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella Witman, GB, Hou, Y, Pazour, GJ, Follit, JA, Qin, H, Rosenbaum, JL	J. Cell Biol.	2007
19450523	SnapShot: Intraflagellar transport Snell, WJ, Cole, DG	Cell	2009
23990561	Molecular basis of tubulin transport within the cilium by IFT74 and IFT81 Weber, K, Mizuno, N, Fort, C, Bhogaraju, S, Blisnick, T, Nigg, EA, Lamla, S, Bastin, P, Taschner, M, Lorentzen, E, Cajanek, L	Science	2013
18852297	ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery Mitchell, DR, Lucker, BF, Gao, C, Ahmed, NT, Cole, DG	J. Cell Biol.	2008
24596149	TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella Stainier, DY, Ide, T, Jiang, X, Ishikawa, H, Marshall, WF, Qin, H, Kamiya, R, Wemmer, KA, Yagi, T, Sasaki, H, Hirono, M, Yanagisawa, H	Elife	2014
24616010	Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites? Weber, K, Bhogaraju, S, Lechtreck, KF, Engel, BD, Lorentzen, E	Bioessays	2014