Reactome | PKN1:AR complex binds promoters of KLK2 and KLK3 genes

PKN1:AR complex binds promoters of KLK2 and KLK3 genes

Stable Identifier

R-HSA-5625774

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

PKN1:AR complex binds promoters of KLK2 and KLK3 genes

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PKN1 in complex with the activated AR (androgen receptor) binds promoters of KLK2 and KLK3 (PSA) genes (Metzger et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18066052	Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation Kunowska, N, Patnaik, D, Schüle, R, Metzger, E, Wissmann, M, Potier, N, Scheidtmann, KH, Higgins, JM, Friedrichs, N, Buettner, R, Fischer, K, Yin, N	Nat. Cell Biol.	2008