KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625797
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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KDM4C (JMJD2C) demethylates trimethylated lysine K10 of histone 3 in nucleosomes associated with promoters of KLK2 and KLK3 (PSA) genes (Metzger et al. 2008), converting it to dimethylated lysine (Whetstine et al. 2006).

Literature References
PubMed ID Title Journal Year
16603238 Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Whetstine, JR, Nottke, A, Lan, F, Huarte, M, Smolikov, S, Chen, Z, Spooner, E, Li, E, Zhang, G, Colaiácovo, MP, Shi, Y

Cell 2006
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R

Nat. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created