KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters

Stable Identifier
R-HSA-5625870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PKN1-mediated phosphorylation of histone H3 threonine residue T12 (also labeled in literature as Thr11) enables demethylation of histone H3 lysine K10 (also labeled in literature as K9) by demethylase KDM1A (LSD1) (Metzger et al. 2008). KDM1A acts on dimethylated and monomethylated H3K9 at AR-regulated promoters (Metzger et al. 2005), so it is shown that KDM1A-mediated demethylation of monomethylated H3K9 (MeK-10-H3) happens sequentially after KDM1A-mediated demethylation of dimethylated H3K9 (Me2K-10-H3).

Literature References
PubMed ID Title Journal Year
16079795 LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Metzger, E, Wissmann, M, Yin, N, Müller, JM, Schneider, R, Peters, AH, Günther, T, Buettner, R, Schüle, R

Nature 2005
18066052 Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

Metzger, E, Yin, N, Wissmann, M, Kunowska, N, Fischer, K, Friedrichs, N, Patnaik, D, Higgins, JM, Potier, N, Scheidtmann, KH, Buettner, R, Schüle, R

Nat. Cell Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1A [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created