RHO GTPases activate KTN1

Stable Identifier
R-HSA-5625970
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

GTP-bound active forms of RHO GTPases RHOA, RHOG, RAC1 and CDC42 bind kinectin (KTN1), a protein inserted in endoplasmic reticulum membranes that interacts with the cargo-binding site of kinesin and activates its microtubule-stimulated ATPase activity required for vesicle motility (Vignal et al. 2001, Hotta et al. 1996). The effect of RHOG activity on cellular morphology, exhibited in the formation of microtubule-dependent cellular protrusions, depends both on RHOG interaction with KTN1, as well as on the kinesin activity (Vignal et al. 2001). RHOG and KTN1 also cooperate in microtubule-dependent lysosomal transport (Vignal et al. 2001). The precise mechanism of kinectin-mediated Rho GTPase signaling cascade needs further elucidation, and only the first two steps, KTN1-activated RHO GTPase binding, and KTN1-kinesin-1 binding are annotated here.

Literature References
PubMed ID Title Journal Year
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
11689693 Kinectin is a key effector of RhoG microtubule-dependent cellular activity

Vignal, E, Blangy, A, Martin, M, Gauthier-Rouvière, C, Fort, P

Mol. Cell. Biol. 2001
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