C2CD3 binds the mother centriole

Stable Identifier
R-HSA-5626220
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

C2 domain-containing protein 3 (C2CD3) is basal body-localized protein that is required for ciliogenesis and Hh signaling (Hoover et al, 2008; Balestra et al, 2013). C2CD3 is recruited to the centrosome in a pericentriolar material 1 protein (PCM1)- and microtubule-dependent manner and is required for the subsequent recruitment of the distal appendage proteins to the mother centriole (Tanos et al, 2013; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014). The distal appendage proteins are thought to be a component of the transition fibres that anchor the basal body to the membrane at the base of the cilium and are themselves required for the recruitment of Tau-tubulin kinase 2 (TTBK2) and for docking ciliary vesicles to the mother centriole (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2013; Schmidt et al, 2012; Sillibourne et al, 2013; Burke et al, 2014).

Literature References
PubMed ID Title Journal Year
24469809 C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A

Proc. Natl. Acad. Sci. U.S.A. 2014
25313408 Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation

Burke, MC, Li, FQ, Cyge, B, Arashiro, T, Brechbuhl, HM, Chen, X, Siller, SS, Weiss, MA, O'Connell, CB, Love, D, Westlake, CJ, Reynolds, SD, Kuriyama, R, Takemaru, K

J. Cell Biol. 2014
23253480 Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

Schmidt, KN, Kuhns, S, Neuner, A, Hub, B, Zentgraf, H, Pereira, G

J. Cell Biol. 2012
23769972 Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells

Balestra, FR, Strnad, P, Flückiger, I, Gönczy, P

Dev. Cell 2013
23348840 Centriole distal appendages promote membrane docking, leading to cilia initiation

Tanos, BE, Yang, HJ, Soni, R, Wang, WJ, Macaluso, FP, Asara, JM, Tsou, MF

Genes Dev. 2013
19004860 C2cd3 is required for cilia formation and Hedgehog signaling in mouse

Hoover, AN, Wynkoop, A, Zeng, H, Jia, J, Niswander, LA, Liu, A

Development 2008
23530209 CCDC41 is required for ciliary vesicle docking to the mother centriole

Joo, K, Kim, CG, Lee, MS, Moon, HY, Lee, SH, Kim, MJ, Kweon, HS, Park, WY, Kim, CH, Gleeson, JG, Kim, J

Proc. Natl. Acad. Sci. U.S.A. 2013
25047611 Centriole structure

Winey, M, O'Toole, E

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2014
19940019 Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling

Li, FQ, Mofunanya, A, Fischer, V, Hall, J, Takemaru, K

Mol. Biol. Cell 2010
23789104 Primary ciliogenesis requires the distal appendage component Cep123

Sillibourne, JE, Hurbain, I, Grand-Perret, T, Goud, B, Tran, P, Bornens, M

Biol Open 2013
24231678 Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Wei, Q, Xu, Q, Zhang, Y, Li, Y, Zhang, Q, Hu, Z, Harris, PC, Torres, VE, Ling, K, Hu, J

Nat Commun 2013
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