Reactome | C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

Stable Identifier

R-HSA-5626223

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

Centrosome:C2CD3 binds distal appendage proteins

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C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole

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C2CD3 and the centrosome component OFD1 are required for the recruitment of distal appendage proteins CEP164, CEP83/CCDC41, CEP89, FBF1 and SCLT1 to the mother centriole (Ye et al, 2014; Tang et al, 2013; Singla et al, 2010). Distal appendage proteins are believed to form part of the transition fibres that anchor the basal bodies to the actin rich cortex at the base of the emerging cilium, and are also required for the recruitment and binding of ciliary vesicles and intraflagellar transport (IFT) complexes (Tanos et al, 2013; Wei et al, 2013; Joo et al, 2010; Schmidt et al, 2012; Sillibourne et al, 2013; Ye et al, 2014; reviewed in Winey and O'Toole, 2014).

Literature References

PubMed ID	Title	Journal	Year
23253480	Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis Schmidt, KN, Kuhns, S, Neuner, A, Hub, B, Zentgraf, H, Pereira, G	J. Cell Biol.	2012
24469809	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A	Proc. Natl. Acad. Sci. U.S.A.	2014
24089205	Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites Tang, Z, Lin, MG, Stowe, TR, Chen, S, Zhu, M, Stearns, T, Franco, B, Zhong, Q	Nature	2013
23348840	Centriole distal appendages promote membrane docking, leading to cilia initiation Tanos, BE, Yang, HJ, Soni, R, Wang, WJ, Macaluso, FP, Asara, JM, Tsou, MF	Genes Dev.	2013
23530209	CCDC41 is required for ciliary vesicle docking to the mother centriole Joo, K, Kim, CG, Lee, MS, Moon, HY, Lee, SH, Kim, MJ, Kweon, HS, Park, WY, Kim, CH, Gleeson, JG, Kim, J	Proc. Natl. Acad. Sci. U.S.A.	2013
25047611	Centriole structure Winey, M, O'Toole, E	Philos. Trans. R. Soc. Lond., B, Biol. Sci.	2014
20230748	Ofd1, a human disease gene, regulates the length and distal structure of centrioles Singla, V, Romaguera-Ros, M, García-Verdugo, JM, Reiter, JF	Dev. Cell	2010
23789104	Primary ciliogenesis requires the distal appendage component Cep123 Sillibourne, JE, Hurbain, I, Grand-Perret, T, Goud, B, Tran, P, Bornens, M	Biol Open	2013
24231678	Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes Wei, Q, Xu, Q, Zhang, Y, Li, Y, Zhang, Q, Hu, Z, Harris, PC, Torres, VE, Ling, K, Hu, J	Nat Commun	2013