Reactome | TCTN2 [ciliary membrane]

TCTN2 [ciliary membrane]

Stable Identifier

R-HSA-5626661

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary membrane

Synonyms

TECT2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96GX1 TCTN2

Gene Names

TCTN2, C12orf38, TECT2

Chain

signal peptide:1-25, chain:26-697

Reference Genes

BioGPS Gene:79867 TCTN2

COSMIC (genes):TCTN2 TCTN2

CTD Gene:79867 TCTN2

dbSNP Gene:79867 TCTN2

ENSEMBL:ENSG00000168778 TCTN2

HGNC:25774 TCTN2

Monarch:79867 TCTN2

NCBI Gene:79867 TCTN2

OMIM:613846 TCTN2

UCSC:Q96GX1 TCTN2

Reference Transcript

Other Identifiers

11739580_at

16758671

206438_PM_x_at

206438_x_at

239928_PM_at

239928_at

3435981

3435982

3435983

3435985

3435986

3435989

3435990

3435991

3435992

3435993

3435994

3435995

3435996

3435997

3435998

3435999

3436000

3436001

3436002

3436003

3436004

3436005

3436006

3436007

3436009

3436010

3436012

3436013

3436014

3436015

3436016

3436017

3436018

3436019

3436020

74436_at

75189_at

7959638

79867

A_14_P111834

A_23_P64712

GE88142

GO:0005737

GO:0005856

GO:0007224

GO:0016020

GO:0030030

GO:0035869

GO:0036038

GO:0042995

GO:0043226

GO:0044782

GO:0060170

GO:0060271

GO:1904491

HMNXSV003050418

HMNXSV003055744

Hs.129212.0.A1_3p_at

ILMN_1706345

PH_hs_0010045

TC12000992.hg

g13376192_3p_at

Participates

as a component of

Tectonic-like complex [cytosol] (Homo sapiens)

Inferred To

tctn2 [ciliary membrane] (Xenopus tropicalis)

Tctn2 [ciliary membrane] (Mus musculus)

Tctn2 [ciliary membrane] (Rattus norvegicus)

TCTN2 [ciliary membrane] (Bos taurus)

TCTN2 [ciliary membrane] (Gallus gallus)

TCTN2 [ciliary membrane] (Sus scrofa)

Ghost homologue of TCTN2 [ciliary membrane] (Canis familiaris)

Cross References

ENSEMBL

ENSP00000395171, ENSP00000304941, ENST00000303372, ENST00000426174

OpenTargets

ENSG00000168778

HPA

ENSG00000168778-TCTN2

PRO

Q96GX1

Pharos - Targets

Q96GX1

GlyGen

Q96GX1

Orphanet

TCTN2

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0U3 MAGT1	2	MAGT1 [azurophil granule membrane] (R-HSA-6799208) MAGT1 [plasma membrane] (R-HSA-4836523)	0.619	4
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.619	4
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.615	4
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.527	2
UniProt:P26572 MGAT1	1	MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-964750)	0.527	2
UniProt:Q75T13 PGAP1	1	PGAP1 [endoplasmic reticulum membrane] (R-HSA-162810)	0.527	2
UniProt:Q99758 ABCA3	11	ABCA3 [lamellar body membrane] (R-HSA-1369005) ABCA3 T1114M [lamellar body membrane] (R-HSA-5688390) ABCA3 N568D [lamellar body membrane] (R-HSA-5688388) ABCA3 E690K [lamellar body membrane] (R-HSA-5688389) ABCA3 E292V [lamellar body membrane] (R-HSA-5688394) ABCA3 L1553P [lamellar body membrane] (R-HSA-5683671) ABCA3 L326P [lamellar body membrane] (R-HSA-5683666) ABCA3 D253H [lamellar body membrane] (R-HSA-5683697) ABCA3 L101P [lamellar body membrane] (R-HSA-5683658) ABCA3 W1142* [lamellar body membrane] (R-HSA-5683691) ABCA3 T1173R [lamellar body membrane] (R-HSA-5683705)	0.527	2
UniProt:Q14118 DAG1	15	DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) DAG1(654-895) [Golgi membrane] (R-HSA-9913184) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [Golgi lumen] (R-HSA-8932424) GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region] (R-HSA-9913190) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.527	2
UniProt:Q9BV10 ALG12	7	ALG12 T67M [endoplasmic reticulum membrane] (R-HSA-4722118) ALG12 G101R [endoplasmic reticulum membrane] (R-HSA-4722101) ALG12 L158P [endoplasmic reticulum membrane] (R-HSA-4722115) ALG12 R146Q [endoplasmic reticulum membrane] (R-HSA-4722098) ALG12 F142V [endoplasmic reticulum membrane] (R-HSA-4722108) ALG12 Y414* [endoplasmic reticulum membrane] (R-HSA-4722121) ALG12 [endoplasmic reticulum membrane] (R-HSA-449348)	0.527	2
UniProt:Q6UX41 BTNL8	1	BTNL8 [plasma membrane] (R-HSA-8852007)	0.527	2
UniProt:Q86XF0 DHFR2	1	DHFR2 [cytosol] (R-HSA-2975816)	0.527	2
UniProt:Q92521 PIGB	1	PIGB [endoplasmic reticulum membrane] (R-HSA-162720)	0.527	2
UniProt:P07225 PROS1	8	11xCbxE-PROS1 [extracellular region] (R-HSA-202772) 11xCbxE-PROS1 [plasma membrane] (R-HSA-141004) PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159758) 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159770) 11xCbxE-PROS1(25-676) [Golgi membrane] (R-HSA-159850) PROS1(25-41) [Golgi lumen] (R-HSA-159792) 11xCbxE-PROS1 [Golgi membrane] (R-HSA-159865) 11xCbxE-PROS1 [platelet alpha granule lumen] (R-HSA-349762)	0.527	2
UniProt:Q16585 SGCB	3	SGCB [endoplasmic reticulum membrane] (R-HSA-9913185) SGCB [Golgi membrane] (R-HSA-9913180) SGCB [plasma membrane] (R-HSA-9630718)	0.527	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.508	2
UniProt:Q9H6U8 ALG9	3	ALG9 E523K [endoplasmic reticulum membrane] (R-HSA-4720482) ALG9 Y286C [endoplasmic reticulum membrane] (R-HSA-4720474) ALG9 [endoplasmic reticulum membrane] (R-HSA-449241)	0.483	3

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