Reactome | MARK4 binds ODF2 in the centriole

MARK4 binds ODF2 in the centriole

Stable Identifier

R-HSA-5626699

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MARK4 (microtubule associated protein/microtubule affinity regulating kinase 4) was identified in a screen as a positive regulator of ciliogenesis (Kuhns et al, 2013). MARK4 interacts at the centriole with the subdistal appendage component ODF2 and this interaction is required to promote axonemal extension (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013). Like Tau tubulin kinase 2 (TTBK2), MARK4 appears to have a role in promoting the dissociation of CCP110 and CEP97, uncapping the centriole and allowing axonemal extension to take place (Kuhns et al, 2013; Ye et al, 2014;; Goetz et al, 2012). Although this reaction shows that MARK4 is recruited to the centriole subsequent to TTBK2, the timing of the ODF2:MARK4 interaction is not known.

Literature References

PubMed ID	Title	Journal	Year
24469809	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A	Proc. Natl. Acad. Sci. U.S.A.	2014
23747070	Assembling a primary cilium Kim, S, Dynlacht, BD	Curr. Opin. Cell Biol.	2013
23400999	The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis Kuhns, S, Schmidt, KN, Reymann, J, Gilbert, DF, Neuner, A, Hub, B, Carvalho, R, Wiedemann, P, Zentgraf, H, Erfle, H, Klingmüller, U, Boutros, M, Pereira, G	J. Cell Biol.	2013
23141541	The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis Goetz, SC, Liem, KF, Anderson, KV	Cell	2012