MARK4 binds ODF2 in the centriole

Stable Identifier
R-HSA-5626699
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MARK4 (microtubule associated protein/microtubule affinity regulating kinase 4) was identified in a screen as a positive regulator of ciliogenesis (Kuhns et al, 2013). MARK4 interacts at the centriole with the subdistal appendage component ODF2 and this interaction is required to promote axonemal extension (Kuhns et al, 2013; reviewed in Kim and Dynlacht, 2013). Like Tau tubulin kinase 2 (TTBK2), MARK4 appears to have a role in promoting the dissociation of CCP110 and CEP97, uncapping the centriole and allowing axonemal extension to take place (Kuhns et al, 2013; Ye et al, 2014;; Goetz et al, 2012). Although this reaction shows that MARK4 is recruited to the centriole subsequent to TTBK2, the timing of the ODF2:MARK4 interaction is not known.

Literature References
PubMed ID Title Journal Year
23747070 Assembling a primary cilium

Kim, S, Dynlacht, BD

Curr. Opin. Cell Biol. 2013
24469809 C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Ye, X, Zeng, H, Ning, G, Reiter, JF, Liu, A

Proc. Natl. Acad. Sci. U.S.A. 2014
23400999 The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

Kuhns, S, Schmidt, KN, Reymann, J, Gilbert, DF, Neuner, A, Hub, B, Carvalho, R, Wiedemann, P, Zentgraf, H, Erfle, H, Klingmüller, U, Boutros, M, Pereira, G

J. Cell Biol. 2013
23141541 The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis

Goetz, SC, Liem, KF, Anderson, KV

Cell 2012
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