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RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane
Stable Identifier
R-HSA-5627071
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi-associated vesicle membrane
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases regulate CFTR trafficking (Homo sapiens)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Homo sapiens)
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While binding of GOPC (also known as CAL, PIST or FIG) to CFTR (cystic fibrosis transmembrane conductance regulator) promotes lysosomal degradation of CFTR, binding of active RHOQ to GOPC:CFTR complex redirects CFTR to the plasma membrane and prevents its degradation (Cheng et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15546864
Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10
Cheng, J
,
Guggino, WB
,
Wang, H
J. Biol. Chem.
2005
Participants
Input
RHOQ:GTP:GOPC:CFTR [Golgi-associated vesicle membrane]
(Homo sapiens)
Output
RHOQ:GTP:GOPC:CFTR [plasma membrane]
(Homo sapiens)
Participates
as an event of
RHO GTPases regulate CFTR trafficking (Homo sapiens)
This event is regulated
Positively by
Regulator
RHOQ:GTP:GOPC:CFTR [Golgi-associated vesicle membrane]
(Homo sapiens)
Orthologous Events
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Caenorhabditis elegans)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Canis familiaris)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Gallus gallus)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Rattus norvegicus)
RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)
Authored
Orlic-Milacic, M (2014-10-24)
Rivero Crespo, F (2014-12-26)
Created
Orlic-Milacic, M (2014-10-14)
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