RHO GTPases regulate CFTR trafficking

Stable Identifier
R-HSA-5627083
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Pathway
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Homo sapiens
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Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR (Neudauer et al. 2001, Cheng et al. 2005).

Literature References
PubMed ID Title Journal Year
11162552 PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10

Neudauer, CL, Joberty, G, Macara, IG

Biochem. Biophys. Res. Commun. 2001
15546864 Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

Cheng, J, Wang, H, Guggino, WB

J. Biol. Chem. 2005
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