Reactome: A Curated Pathway Database

RHO GTPases regulate CFTR trafficking

Stable Identifier
R-HSA-5627083
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR (Neudauer et al. 2001, Cheng et al. 2005).

Literature References
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Orthologous Events