RHO GTPases regulate CFTR trafficking

Stable Identifier
R-HSA-5627083
DOI
10.3180/R-HSA-5627083.2
Type
Pathway
Species
Homo sapiens
Compartment
Golgi-associated vesicle membrane, lysosomal membrane, plasma membrane
ReviewStatus
5/5
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RHO GTPases regulate CFTR trafficking
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Activated RHO GTPase RHOQ (TC10) regulates the trafficking of CFTR (cystic fibrosis transmembrane conductance regulator) by binding to GOPC (Golgi-associated and PDZ and coiled-coil motif-containing protein) also known as PIST, FIG or CAL. GOPC is a Golgi resident protein that binds several membrane proteins, thereby modulating their expression. In the absence of RHOQ, GOPC bound to CFTR directs CFTR for lysosomal degradation, while GTP-bound RHOQ directs GOPC:CFTR complex to the plasma membrane, thereby rescuing CFTR (Neudauer et al. 2001, Cheng et al. 2005).
Literature References
PubMed ID Title Journal Year
15546864 Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

Cheng, J, Guggino, WB, Wang, H

J. Biol. Chem. 2005
11162552 PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10

Joberty, G, Macara, IG, Neudauer, CL

Biochem. Biophys. Res. Commun. 2001
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Orthologous Events
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Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-14)
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