Reactome | GOPC [lysosomal membrane]

GOPC [lysosomal membrane]

Stable Identifier

R-HSA-5627281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Golgi-associated PDZ and coiled-coil motif-containing protein, PIST, CAL, FIG

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases regulate CFTR trafficking (Homo sapiens)
        
        GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)
        
        GOPC:CFTR [lysosomal membrane] (Homo sapiens)
        
        GOPC dimer [lysosomal membrane] (Homo sapiens)
        
        GOPC [lysosomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HD26 GOPC

Gene Names

GOPC, CAL, FIG

Chain

initiator methionine:1, chain:2-462

Reference Genes

BioGPS Gene:57120 GOPC

COSMIC (genes):GOPC GOPC

CTD Gene:57120 GOPC

dbSNP Gene:57120 GOPC

ENSEMBL:ENSG00000047932.14 GOPC

HGNC:17643 GOPC

KEGG Gene (Homo sapiens):57120 GOPC

Monarch:57120 GOPC

NCBI Gene:57120 GOPC

OMIM:606845 GOPC

UCSC:Q9HD26 GOPC

Reference Transcript

Other Identifiers

0002260044

11741271_a_at

11741272_a_at

17023051

225022_PM_at

225022_at

225023_PM_at

225023_at

227214_PM_at

227214_at

227215_PM_at

227215_at

2971379

2971380

2971381

2971382

2971385

2971386

2971387

2971388

2971390

2971391

2971392

2971395

2971399

2971400

2971401

2971402

45322_at

57120

59685_s_at

74349_at

8129181

88844_at

A_23_P336040

A_23_P58877

GE88507

GO:0000139

GO:0005515

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005886

GO:0006888

GO:0006893

GO:0010360

GO:0014069

GO:0015031

GO:0016020

GO:0016192

GO:0030140

GO:0030425

GO:0030660

GO:0031410

GO:0032991

GO:0042802

GO:0042995

GO:0043004

GO:0043226

GO:0044325

GO:0045176

GO:0045202

GO:0055085

GO:0072659

GO:2000009

HMNXSV003058053

Hs.126268.0.S1_3p_at

Hs.126268.0.S2_3p_at

Hs.126268.0.S2_3p_x_at

Hs.23120.0.S1_3p_at

Hs.23120.0.S2_3p_at

ILMN_1695842

ILMN_2388585

PH_hs_0022918

TC06003826.hg

TC06004056.hg

Participates

as a component of

GOPC dimer [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

GOPC [plasma membrane]

GOPC [Golgi-associated vesicle membrane]

Inferred To

GOPC [lysosomal membrane] (Bos taurus)

GOPC [lysosomal membrane] (Canis familiaris)

GOPC [lysosomal membrane] (Danio rerio)

GOPC [lysosomal membrane] (Gallus gallus)

GOPC [lysosomal membrane] (Sus scrofa)

Gopc [lysosomal membrane] (Mus musculus)

gopc [lysosomal membrane] (Xenopus tropicalis)

gopc-1 [lysosomal membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065132.1, NP_001017408.1

OpenTargets

ENSG00000047932

HPA

ENSG00000047932-GOPC

GeneCards

Q9HD26

Ensembl

ENST00000368498, ENSP00000052569, ENSG00000047932, ENST00000052569, ENSP00000357484

PRO

Q9HD26

Pharos - Targets

Q9HD26

Orphanet

25778

HMDB Protein

HMDBP08220

PDB

4NMT, 4NMO, 6XNJ, 2DC2, 4NMP, 4JOK, 5K4F, 4Q6H, 6OV7, 4JOJ, 4JOF, 4NMS, 4K76, 7JZR, 6V84, 4JOG, 5IC3, 7JZQ, 4JOH, 4K78, 4K72, 4JOR, 4E35, 4K6Y, 4E34, 7JZP, 4JOE, 4Q6S, 4K75, 4NMR, 4NMV, 4NMQ, 4JOP, 2LOB, 7JZO

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.71	4
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.666	4
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:Q15746 MYLK	2	p-S1208,S1759-MYLK(1-1914) [cytosol] (R-HSA-5668975) MYLK(1-1914) [cytosol] (R-HSA-445807)	0.556	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.556	3
UniProt:Q6UWP7 LCLAT1	1	LCLAT1 [endoplasmic reticulum membrane] (R-HSA-1498783)	0.556	3
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.556	3

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