Reactome | SLC26A4 transports I- from cytosol to extracellular region

SLC26A4 transports I- from cytosol to extracellular region

Stable Identifier

R-HSA-5627802

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC26A4 transports I- from cytosol to extracellular region

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SLC26 members A3, 4 and 6 are able to exchange chloride for bicarbonate. SLC26A4 (Pendrin) can also mediate the efflux of iodide (I-) from the apical membranes of thyroid and inner ear cells. SLC26A4 is highly expressed in the adult thyroid and its activity is necessary for production of thyroid hormone (Dossena et al. 2006). Mutations in this gene are associated with Pendred syndrome, an autosomal-recessive disease which is the most common form of syndromic deafness and associated goitre.

Literature References

PubMed ID	Title	Journal	Year
16914891	Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity Storelli, C, Paulmichl, M, Persani, L, Beck-Peccoz, P, Bottá, G, Vezzoli, V, Bazzini, C, Meyer, G, Rodighiero, S, Fugazzola, L, Sironi, C, Zorowka, P, Garavaglia, ML, Ritter, M, Fürst, J, Dossena, S	Cell. Physiol. Biochem.	2006