Reactome | NDRG1 [cytosol]

NDRG1 [cytosol]

Stable Identifier

R-HSA-5628834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein NDRG1, Differentiation-related gene 1 protein, DRG-1, CAP43, RTP, Rit42

Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates NDRG1 gene expression (Homo sapiens)
        
        NDRG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92597 NDRG1

Gene Names

NDRG1, CAP43, DRG1, RTP

Chain

initiator methionine:, chain:2-394

Reference Genes

BioGPS Gene:10397 NDRG1

COSMIC (genes):NDRG1 NDRG1

CTD Gene:10397 NDRG1

dbSNP Gene:10397 NDRG1

ENSEMBL:ENSG00000104419 NDRG1

ENSEMBL_homo_sapiens_GENE:ENSG00000104419.17 NDRG1

HGNC:7679 NDRG1

KEGG Gene (Homo sapiens):10397 NDRG1

Monarch:10397 NDRG1

NCBI Gene:10397 NDRG1

OMIM:605262 NDRG1

UCSC:Q92597 NDRG1

Reference Transcript

Other Identifiers

10397

11751342_a_at

11751343_x_at

11753232_a_at

11753233_x_at

11753431_x_at

11754337_s_at

17081401

200632_PM_s_at

200632_s_at

3154318

3154319

3154320

3154321

3154322

3154325

3154328

3154333

3154335

3154337

3154340

3154341

3154344

3154346

3154348

3154349

3154352

3154361

3154364

3154365

3154366

3154367

3154368

3154369

36933_at

8153002

A_23_P20494

A_24_P38387

D87953_at

GE57422

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005912

GO:0007165

GO:0008017

GO:0008092

GO:0008285

GO:0010038

GO:0015630

GO:0016020

GO:0023052

GO:0030154

GO:0030330

GO:0031267

GO:0031410

GO:0032287

GO:0043015

GO:0043226

GO:0045296

GO:0045576

GO:0048471

GO:0048856

GO:0055038

GO:0061024

GO:0070062

GO:0071456

HMNXSV003049419

ILMN_1809931

PH_hs_0029732

g5174656_3p_s_at

Participates

as an output of

TP53 stimulates NDRG1 gene expression (Homo sapiens)

Cross References

RefSeq

NP_001245361.1, NP_001128714.1, NP_006087.2, NP_001245362.1

OpenTargets

ENSG00000104419

HPA

ENSG00000104419-NDRG1

GeneCards

Q92597

Ensembl

ENSG00000104419, ENSP00000404854, ENST00000522476, ENSP00000319977, ENST00000414097, ENST00000323851, ENSP00000427894

PRO

Q92597

Pharos - Targets

Q92597

Orphanet

16524

HMDB Protein

HMDBP01733

PDB

6ZMM

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.671	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.604	3
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.564	2
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q9H6J7-2 CSTPP1			0.556	3
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.556	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
IntAct:EBI-25832170 ORF			0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:Q6PID6 TTC33			0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q9H816 DCLRE1B	1	DCLRE1B [nucleoplasm] (R-HSA-6785735)	0.556	3
UniProt:O00168 FXYD1	1	FXYD1 [plasma membrane] (R-HSA-2752086)	0.527	2
UniProt:O95136 S1PR2	1	S1PR2 [plasma membrane] (R-HSA-419419)	0.527	2
UniProt:Q9NP50 SHCAF			0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.499	3
UniProt:P20338 RAB4A	5	GGC-RAB4A [cytoplasmic vesicle membrane] (R-HSA-1458526) GGC-RAB4A [cytosol] (R-HSA-8874045) RAB4A [cytosol] (R-HSA-8873709) RAB4A [early endosome membrane] (R-HSA-8871356) GGC-RAB4A [recycling endosome membrane] (R-HSA-8875666)	0.463	2

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