TP53 stimulates TIGAR expression

Stable Identifier
R-HSA-5628901
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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TIGAR was first identified as a TP53 target through high-throughput gene expression profiling (Jen and Cheung 2005). TP53 stimulates TIGAR transcription, although TIGAR can be regulated through TP53-independent mechanisms, including TP53 family members TP63 (p63) and TP73 (p73). TIGAR is induced by TP53 under low stress levels and decreases under high stress levels (Bensaad et al. 2006). TIGAR functions as a fructose-2,6-bisphosphatase, thereby lowering glycolytic flux and promoting antioxidant functions. By protecting cells from oxidative stress, TIGAR may mediate some of the tumor suppressor activity of p53 but could also contribute to tumorigenesis. (Bensaad, 2006, Lee et al. 2014).

Literature References
PubMed ID Title Journal Year
16839880 TIGAR, a p53-inducible regulator of glycolysis and apoptosis

Bensaad, K, Tsuruta, A, Selak, MA, Vidal, MN, Nakano, K, Bartrons, R, Gottlieb, E, Vousden, KH

Cell 2006
26652033 Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73

Venkatanarayan, A, Raulji, P, Norton, W, Flores, ER

Cell Cycle 2016
16140933 Identification of novel p53 target genes in ionizing radiation response

Jen, KY, Cheung, VG

Cancer Res. 2005
24383451 TIGAR, TIGAR, burning bright

Lee, P, Vousden, KH, Cheung, EC

Cancer Metab 2014
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