TP53 binds regulatory elements of SESN1,2,3 genes

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R-HSA-5629187
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Reaction
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Homo sapiens
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TP53 (p53) binds to the p53 response element in the intron 2 of SESN1 gene and stimulates transcription of SESN1 transcripts SESN1-1 and SESN1-3, also known as PA26 T2 and PA26 T3 (Velasco-Miguel et al. 1999). Recently, TP53 binding to SESN2 gene regulatory elements has been identified by ChIPseq (Menendez et al. 2013), and SESN2 gene expression was previously shown to be responsive to TP53 (Budanov et al. 2002). Rat ortholog of SESN3 was shown to possess p53 binding sites in the promoter region, but direct binding of TP53 to regulatory elements of human SESN3 has not been examined (Brynczka et al. 2007).

Literature References
PubMed ID Title Journal Year
9926927 PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S, Buckbinder, L, Jean, P, Gelbert, L, Talbott, R, Laidlaw, J, Seizinger, B, Kley, N

Oncogene 1999
23775793 Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

Menendez, D, Nguyen, TA, Freudenberg, JM, Mathew, VJ, Anderson, CW, Jothi, R, Resnick, MA

Nucleic Acids Res. 2013
17540029 NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation

Brynczka, C, Labhart, P, Merrick, BA

BMC Genomics 2007
12203114 Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Budanov, AV, Shoshani, T, Faerman, A, Zelin, E, Kamer, I, Kalinski, H, Gorodin, S, Fishman, A, Chajut, A, Einat, P, Skaliter, R, Gudkov, AV, Chumakov, PM, Feinstein, E

Oncogene 2002
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