Reactome | SESN1,2,3 bind AMPK

SESN1,2,3 bind AMPK

Stable Identifier

R-HSA-5631941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SESN1, SESN2 and possibly SESN3 are able to bind the AMPK complex and increase its catalytic activity. The exact mechanism has not been elucidated, but recent studies suggest that sestrin-bound AMPK is resistant to inactivation through AKT-induced dephosphorylation (Budanov and Karin 2008, Sanli et al. 2012, Cam et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
22363791	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells Tsakiridis, T, Linher-Melville, K, Singh, G, Sanli, T	PLoS ONE	2012
24366874	p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage Zambetti, GP, Houghton, PJ, Bid, HK, Cam, H, Xiao, L, Cam, M	J. Biol. Chem.	2014
18692468	p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling Budanov, AV, Karin, M	Cell	2008