Reactome | DDIT4 [cytosol]

DDIT4 [cytosol]

Stable Identifier

R-HSA-5632374

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DNA damage-inducible transcript 4 protein, REDD1, HIF-1 responsive protein RTP801, RTP801

Locations in the PathwayBrowser for interactor UniProt:P61086 UBE2K

Expand all

External Reference Information

External Reference

UniProt:Q9NX09 DDIT4

Gene Names

DDIT4, REDD1, RTP801

Chain

chain:1-232

Reference Genes

BioGPS Gene:54541 DDIT4

COSMIC (genes):DDIT4 DDIT4

CTD Gene:54541 DDIT4

dbSNP Gene:54541 DDIT4

ENSEMBL:ENSG00000168209 DDIT4

ENSEMBL_homo_sapiens_GENE:ENSG00000168209.6 DDIT4

HGNC:24944 DDIT4

KEGG Gene (Homo sapiens):54541 DDIT4

Monarch:54541 DDIT4

NCBI Gene:54541 DDIT4

OMIM:607729 DDIT4

UCSC:Q9NX09 DDIT4

Reference Transcript

RefSeq:NM_019058.3 DDIT4

Other Identifiers

11743972_a_at

16705961

202887_PM_s_at

202887_s_at

3251401

3251403

3251404

3251406

3251407

3251408

3251409

3251410

39827_at

43853_at

54541

64010_s_at

7928308

A_14_P122194

A_23_P104318

GE80055

GO:0001666

GO:0001764

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006091

GO:0006915

GO:0007420

GO:0009968

GO:0012501

GO:0023052

GO:0030154

GO:0030182

GO:0032007

GO:0032984

GO:0035556

GO:0042771

GO:0043226

GO:0045820

GO:0048011

GO:0048856

GO:0048870

GO:0051607

GO:0055086

GO:0071549

GO:0071889

GO:0072593

GO:0098542

GO:1901135

HMNXSV003011933

ILMN_1661599

PH_hs_0006110

TC10000449.hg

g9506686_3p_s_at

Participates

as an output of

TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)

as a component of

DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)

as an input of

DDIT4 binds 14-3-3 dimer (Homo sapiens)

Inferred To

Homologues of DDIT4 [cytosol] (Drosophila melanogaster)

ddit4 [cytosol] (Danio rerio)

ddit4 [cytosol] (Xenopus tropicalis)

scyl [cytosol] (Drosophila melanogaster)

Ddit4 [cytosol] (Mus musculus)

Ddit4 [cytosol] (Rattus norvegicus)

DDIT4 [cytosol] (Bos taurus)

DDIT4 [cytosol] (Canis familiaris)

DDIT4 [cytosol] (Gallus gallus)

DDIT4 [cytosol] (Sus scrofa)

chrb [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_061931.1

OpenTargets

ENSG00000168209

GeneCards

Q9NX09

HPA

ENSG00000168209-DDIT4

Ensembl

ENSP00000307305, ENST00000491934, ENST00000307365, ENSG00000168209, ENSP00000506356

PRO

Q9NX09

Pharos - Targets

Q9NX09

PDB

3LQ9, 7MOP

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P57682 KLF3			0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:P58304 VSX2			0.556	3
IntAct:EBI-25850457 CCSB			0.556	3
UniProt:P08195-4 SLC3A2			0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:Q9Y483-4 MTF2			0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q6P1K2 PMF1	1	PMF1 [cytosol] (R-HSA-375320)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.462	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.462	2

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