TP63/TP53 stimulates transcription of DDIT4 gene

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R-HSA-5632386
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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Transcription of DDIT4 (REDD1) gene is stimulated by TP63, both during mouse embryonal development and under conditions of genotoxic and oxidative stress. TP53 stimulates DDIT4 transcription after TP53 activation by ionizing radiation, but it seems that TP63 is the main activator of DDIT4 transcription under stress conditions (Ellisen et al. 2002).

Literature References
PubMed ID Title Journal Year
12453409 REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

Ellisen, LW, Ramsayer, KD, Johannessen, CM, Yang, A, Beppu, H, Minda, K, Oliner, JD, McKeon, F, Haber, DA

Mol. Cell 2002
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