Reactome | ADRBK1 [cilium]

ADRBK1 [cilium]

Stable Identifier

R-HSA-5632504

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

GRK2, BARK, BARK1

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External Reference Information

External Reference

UniProt:P25098 GRK2

Gene Names

GRK2, ADRBK1, BARK, BARK1

Chain

chain:1-689

Reference Genes

BioGPS Gene:156 GRK2

CTD Gene:156 GRK2

dbSNP Gene:156 GRK2

ENSEMBL:ENSG00000173020 GRK2

HGNC:289 GRK2

KEGG Gene (Homo sapiens):156 GRK2

Monarch:156 GRK2

NCBI Gene:156 GRK2

OMIM:109635 GRK2

UCSC:P25098 GRK2

Reference Transcript

RefSeq:NM_001619.3 GRK2

Other Identifiers

0003120273

0100360519

11716022_at

11716023_s_at

156

16727702

201401_s_at

201402_at

3336802

3336803

3336818

3336820

3336822

3336823

3336824

3336825

3336827

3336828

3336829

3336830

3336832

3336833

3336834

3336835

3336837

3336839

3336842

3336845

3336847

3336849

3336850

3336851

3336852

3336853

3336854

3336855

3336856

38447_at

7941797

A_23_P202667

A_24_P326635

A_33_P3384392

GE81046

GE87490

GO:0000166

GO:0002026

GO:0002029

GO:0003013

GO:0003108

GO:0003674

GO:0004672

GO:0004674

GO:0004703

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005929

GO:0006464

GO:0006468

GO:0006810

GO:0007165

GO:0007186

GO:0007213

GO:0007217

GO:0007267

GO:0007507

GO:0008150

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019079

GO:0031623

GO:0031694

GO:0031755

GO:0033605

GO:0043167

GO:0043226

GO:0044403

GO:0045202

GO:0045988

GO:0046718

GO:0047696

GO:0048856

GO:0060048

ILMN_1673330

ILMN_3307926

PH_hs_0004771

TC11000682.hg

U08438_at

g179334_3p_s_at

g6138971_3p_at

g6138971_3p_s_at

Participant Of

input

ADRBK1 binds phosphorylated SMO dimer

hasComponent

output

CSNK1A1 and ADRBK1 dissociate from p-SMO dimer

Other forms of this molecule

GRK2 [plasma membrane]

p-S29-ADRBK1 [plasma membrane]

p-S29-ADRBK1 [cytosol]

Inferred To

Gprk1 [cilium] (Drosophila melanogaster)

Adrbk1 [cilium] (Mus musculus)

Grk2 [cilium] (Rattus norvegicus)

grk3 [cilium] (Danio rerio)

ADRBK1 [cilium] (Bos taurus)

ADRBK1 [cilium] (Xenopus tropicalis)

GRK2 [cilium] (Canis familiaris)

Cross References

RefSeq

NP_001610.2

OpenTargets

ENSG00000173020

ZINC - Substances

ARBK1_HUMAN

GeneCards

P25098

HPA

ENSG00000173020-GRK2

Ensembl

ENSP00000312262, ENSG00000173020, ENST00000308595

ZINC - Biogenic

ARBK1_HUMAN

ZINC target

P25098

PRO

P25098

ZINC - Predictions - Purchasable

ARBK1_HUMAN

HMDB Protein

HMDBP01262

PDB

6C2Y, 5UKK, 5UKL, 3CIK, 3KRX, 5WG3, 4PNK, 5WG4, 3KRW, 5UUU, 5HE1, 3V5W, 5WG5, 4MK0, 5UVC, 1BAK

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35626 GRK3	2	ADRBK2 [plasma membrane] (R-HSA-8852029) ADRBK2 [cytosol] (R-HSA-8866004)	0.564	2
UniProt:P25963 NFKBIA	10	p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA [cytosol] (R-HSA-168151) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929) SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935)	0.558	2
UniProt:P0CG48 UBC	325	UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-566-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-338-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-186-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-262-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-414-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-110-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-642-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-488-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130) Ub-443-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783153) Ub-139-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783155) Ub-63-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783094) Ub-671-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783083) Ub-519-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783053) Ub-367-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783105) Ub-215-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783137) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122) Ub-310-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783027) Ub-234-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783157) Ub-614-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783063) Ub-462-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783118) Ub-538-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783011) Ub-158-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783140) Ub-82-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783175) Ub-315-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783089) Ub-163-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783091) Ub-543-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783060) Ub-239-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783092) Ub-619-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783125) Ub-467-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783181) Ub-11-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783104) Ub-391-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783170) Ub-87-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783110) Ub-656-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783134) Ub-124-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783120) Ub-428-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783090) Ub-48-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783029) Ub-504-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783113) Ub-200-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783150) Ub-580-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783119) Ub-276-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783183) Ub-352-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783201) Ub-29-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783064) Ub-182-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783097) Ub-486-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783194) Ub-334-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783199) Ub-638-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783188) Ub-106-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783031) Ub-258-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783016) Ub-562-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783172) Ub-410-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783077) Ub-636-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783128) Ub-104-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783032) Ub-256-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783004) Ub-484-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783156) Ub-27-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783022) Ub-332-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783138) Ub-180-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783107) Ub-408-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783108) Ub-560-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783174) N6-glycyl-L-lysine-UBC(457-532) [cytosol] (R-HSA-8869048) N6-glycyl-L-lysine-UBC(609-684) [cytosol] (R-HSA-8869052) N6-glycyl-L-lysine-UBC(229-304) [cytosol] (R-HSA-8869032) N6-glycyl-L-lysine-UBC(533-608) [cytosol] (R-HSA-8869033) N6-glycyl-L-lysine-UBC(153-228) [cytosol] (R-HSA-8869035) N6-glycyl-L-lysine-UBC(305-380) [cytosol] (R-HSA-8869036) N6-glycyl-L-lysine-UBC(77-152) [cytosol] (R-HSA-8869026) N6-glycyl-L-lysine-UBC(1-76) [cytosol] (R-HSA-8869030) N6-glycyl-L-lysine-UBC(381-456) [cytosol] (R-HSA-8869031) adenylatedG608-UBC(533-608) [nucleoplasm] (R-HSA-8852090) adenylatedG380-UBC(305-380) [nucleoplasm] (R-HSA-8852093) adenylatedG532-UBC(457-532) [nucleoplasm] (R-HSA-8852081) adenylatedG304-UBC(229-304) [nucleoplasm] (R-HSA-8852050) adenylatedG152-UBC(77-152) [nucleoplasm] (R-HSA-8852054) adenylatedG684-UBC(609-684) [nucleoplasm] (R-HSA-8852105) adenylatedG228-UBC(153-228) [nucleoplasm] (R-HSA-8852075) adenylatedG76-UBC(1-76) [nucleoplasm] (R-HSA-8852044) adenylatedG456-UBC(381-456) [nucleoplasm] (R-HSA-8852098) UBC [cytosol] (R-HSA-8853531) adenylatedG380-UBC(305-380) [cytosol] (R-HSA-8852062) adenylatedG608-UBC(533-608) [cytosol] (R-HSA-8852052) adenylatedG76-UBC(1-76) [cytosol] (R-HSA-8852053) adenylatedG304-UBC(229-304) [cytosol] (R-HSA-8852117) adenylatedG684-UBC(609-684) [cytosol] (R-HSA-8852118) adenylatedG152-UBC(77-152) [cytosol] (R-HSA-8852087) adenylatedG532-UBC(457-532) [cytosol] (R-HSA-8852045) adenylatedG228-UBC(153-228) [cytosol] (R-HSA-8852111) adenylatedG456-UBC(381-456) [cytosol] (R-HSA-8852069) Ub-428-UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943062) Ub-656-UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943120) Ub-124-UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943129) Ub-48-UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943079) Ub-352-UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943108) Ub-504-UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943075) Ub-276-UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943106) Ub-580-UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943137) Ub-200-UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943087) UBC(1-76) [plasma membrane] (R-HSA-3149469) UBC(457-532) [plasma membrane] (R-HSA-3149468) UBC(153-228) [plasma membrane] (R-HSA-3149467) UBC(609-684) [plasma membrane] (R-HSA-3149466) UBC(77-152) [plasma membrane] (R-HSA-3149465) UBC(229-304) [plasma membrane] (R-HSA-3149464) UBC(533-608) [plasma membrane] (R-HSA-3149462) UBC(381-456) [plasma membrane] (R-HSA-3149459) UBC(305-380) [plasma membrane] (R-HSA-3149458) UBC(1-76) [endosome membrane] (R-HSA-939187) UBC(533-608) [endosome membrane] (R-HSA-939221) UBC(77-152) [endosome membrane] (R-HSA-939161) UBC(305-380) [endosome membrane] (R-HSA-939196) UBC(457-532) [endosome membrane] (R-HSA-939199) UBC(381-456) [endosome membrane] (R-HSA-939166) UBC(153-228) [endosome membrane] (R-HSA-939170) UBC(609-684) [endosome membrane] (R-HSA-939237) UBC(229-304) [endosome membrane] (R-HSA-939172) UBC(77-152) [endoplasmic reticulum membrane] (R-HSA-8943095) UBC(381-456) [endoplasmic reticulum membrane] (R-HSA-8943126) UBC(533-608) [endoplasmic reticulum membrane] (R-HSA-8943061) UBC(609-684) [endoplasmic reticulum membrane] (R-HSA-8943135) UBC(229-304) [endoplasmic reticulum membrane] (R-HSA-8943103) UBC(153-228) [endoplasmic reticulum membrane] (R-HSA-8943068) UBC(1-76) [endoplasmic reticulum membrane] (R-HSA-8943077) UBC(305-380) [endoplasmic reticulum membrane] (R-HSA-8943084) UBC(457-532) [endoplasmic reticulum membrane] (R-HSA-8943112) Ub-29-UBC(1-76) [cytosol] (R-HSA-5689165) Ub-258-UBC(229-304) [cytosol] (R-HSA-5689167) Ub-334-UBC(305-380) [cytosol] (R-HSA-5689166) Ub-410-UBC(381-456) [cytosol] (R-HSA-5689185) Ub-486-UBC(457-532) [cytosol] (R-HSA-5689176) Ub-562-UBC(533-608) [cytosol] (R-HSA-5689151) Ub-106-UBC(77-152) [cytosol] (R-HSA-5689183) Ub-182-UBC(153-228) [cytosol] (R-HSA-5689169) Ub-638-UBC(609-684) [cytosol] (R-HSA-5689136) Ub-310-UBC(305-380) [cytosol] (R-HSA-5689097) Ub-6-UBC(1-76) [cytosol] (R-HSA-5689091) Ub-462-UBC(457-532) [cytosol] (R-HSA-5689092) Ub-386-UBC(381-456) [cytosol] (R-HSA-5689086) Ub-538-UBC(533-608) [cytosol] (R-HSA-5689104) Ub-158-UBC(153-228) [cytosol] (R-HSA-5689107) Ub-614-UBC(609-684) [cytosol] (R-HSA-5689076) Ub-234-UBC(229-304) [cytosol] (R-HSA-5689110) Ub-82-UBC(77-152) [cytosol] (R-HSA-5689078) Ub-110-UBC(77-152) [cytosol] (R-HSA-5689196) Ub-33-UBC(1-76) [cytosol] (R-HSA-5689134) Ub-488-UBC(457-532) [cytosol] (R-HSA-5689153) Ub-338-UBC(305-380) [cytosol] (R-HSA-5689152) Ub-642-UBC(609-684) [cytosol] (R-HSA-5689218) Ub-414-UBC(381-456) [cytosol] (R-HSA-5689157) Ub-262-UBC(229-304) [cytosol] (R-HSA-5689150) Ub-566-UBC(533-608) [cytosol] (R-HSA-5689205) Ub-186-UBC(153-228) [cytosol] (R-HSA-5689140) Ub-256-UBC(229-304) [cytosol] (R-HSA-5689135) Ub-180-UBC(153-228) [cytosol] (R-HSA-5689221) Ub-104-UBC(77-152) [cytosol] (R-HSA-5689189) Ub-484-UBC(457-532) [cytosol] (R-HSA-5689220) Ub-560-UBC(533-608) [cytosol] (R-HSA-5689145) Ub-636-UBC(609-684) [cytosol] (R-HSA-5689144) Ub-332-UBC(305-380) [cytosol] (R-HSA-5689211) Ub-27-UBC(1-76) [cytosol] (R-HSA-5689179) Ub-408-UBC(381-456) [cytosol] (R-HSA-5689182) Ub-87-UBC(77-152) [cytosol] (R-HSA-3095920) Ub-163-UBC(153-228) [cytosol] (R-HSA-3095924) Ub-619-UBC(609-684) [cytosol] (R-HSA-3095925) Ub-467-UBC(457-532) [cytosol] (R-HSA-3095935) Ub-11-UBC(1-76) [cytosol] (R-HSA-3095906) Ub-543-UBC(533-608) [cytosol] (R-HSA-3095912) Ub-391-UBC(381-456) [cytosol] (R-HSA-3095914) Ub-315-UBC(305-380) [cytosol] (R-HSA-3095916) Ub-239-UBC(229-304) [cytosol] (R-HSA-3095919) Ub-519-UBC(457-532) [endosome membrane] (R-HSA-939227) Ub-367-UBC(305-380) [endosome membrane] (R-HSA-939162) Ub-291-UBC(229-304) [endosome membrane] (R-HSA-939226) Ub-443-UBC(381-456) [endosome membrane] (R-HSA-939204) Ub-215-UBC(153-228) [endosome membrane] (R-HSA-939175) Ub-63-UBC(1-76) [endosome membrane] (R-HSA-939174) Ub-595-UBC(533-608) [endosome membrane] (R-HSA-939242) Ub-139-UBC(77-152) [endosome membrane] (R-HSA-939244) Ub-671-UBC(609-684) [endosome membrane] (R-HSA-939183) Ub-291-UBC(229-304) [plasma membrane] (R-HSA-939859) Ub-595-UBC(533-608) [plasma membrane] (R-HSA-939858) Ub-367-UBC(305-380) [plasma membrane] (R-HSA-939861) Ub-63-UBC(1-76) [plasma membrane] (R-HSA-939860) Ub-139-UBC(77-152) [plasma membrane] (R-HSA-939865) Ub-215-UBC(153-228) [plasma membrane] (R-HSA-939864) Ub-519-UBC(457-532) [plasma membrane] (R-HSA-939845) Ub-671-UBC(609-684) [plasma membrane] (R-HSA-939846) Ub-443-UBC(381-456) [plasma membrane] (R-HSA-939848) Ub-408-UBC(381-456) [nucleoplasm] (R-HSA-6782681) Ub-484-UBC(457-532) [nucleoplasm] (R-HSA-6782650) Ub-104-UBC(77-152) [nucleoplasm] (R-HSA-6782651) Ub-256-UBC(229-304) [nucleoplasm] (R-HSA-6782641) Ub-180-UBC(153-228) [nucleoplasm] (R-HSA-6782603) Ub-560-UBC(533-608) [nucleoplasm] (R-HSA-6782637) Ub-27-UBC(1-76) [nucleoplasm] (R-HSA-6782625) Ub-636-UBC(609-684) [nucleoplasm] (R-HSA-6782597) Ub-332-UBC(305-380) [nucleoplasm] (R-HSA-6782630) Ub-638-UBC(609-684) [nucleoplasm] (R-HSA-6782680) Ub-258-UBC(229-304) [nucleoplasm] (R-HSA-6782621) Ub-562-UBC(533-608) [nucleoplasm] (R-HSA-6782672) Ub-410-UBC(381-456) [nucleoplasm] (R-HSA-6782642) Ub-182-UBC(153-228) [nucleoplasm] (R-HSA-6782678) Ub-106-UBC(77-152) [nucleoplasm] (R-HSA-6782602) Ub-334-UBC(305-380) [nucleoplasm] (R-HSA-6782638) Ub-29-UBC(1-76) [nucleoplasm] (R-HSA-6782659) Ub-486-UBC(457-532) [nucleoplasm] (R-HSA-6782661) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-6782524) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-6782462) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-6782512) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-6782482) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-6782487) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-6782474) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-6782477) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-6782498) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-6782467) Ub-467-UBC(457-532) [nucleoplasm] (R-HSA-6782619) Ub-163-UBC(153-228) [nucleoplasm] (R-HSA-6782622) Ub-11-UBC(1-76) [nucleoplasm] (R-HSA-6782609) Ub-87-UBC(77-152) [nucleoplasm] (R-HSA-6782632) Ub-239-UBC(229-304) [nucleoplasm] (R-HSA-6782669) Ub-543-UBC(533-608) [nucleoplasm] (R-HSA-6782594) Ub-391-UBC(381-456) [nucleoplasm] (R-HSA-6782626) Ub-315-UBC(305-380) [nucleoplasm] (R-HSA-6782660) Ub-619-UBC(609-684) [nucleoplasm] (R-HSA-6782662) Ub-186-UBC(153-228) [nucleoplasm] (R-HSA-6782617) Ub-338-UBC(305-380) [nucleoplasm] (R-HSA-6782620) Ub-33-UBC(1-76) [nucleoplasm] (R-HSA-6782653) Ub-110-UBC(77-152) [nucleoplasm] (R-HSA-6782590) Ub-262-UBC(229-304) [nucleoplasm] (R-HSA-6782640) Ub-642-UBC(609-684) [nucleoplasm] (R-HSA-6782674) Ub-566-UBC(533-608) [nucleoplasm] (R-HSA-6782646) Ub-414-UBC(381-456) [nucleoplasm] (R-HSA-6782636) Ub-488-UBC(457-532) [nucleoplasm] (R-HSA-6782599) Ub-82-UBC(77-152) [nucleoplasm] (R-HSA-6782675) Ub-6-UBC(1-76) [nucleoplasm] (R-HSA-6782611) Ub-234-UBC(229-304) [nucleoplasm] (R-HSA-6782677) Ub-158-UBC(153-228) [nucleoplasm] (R-HSA-6782645) Ub-310-UBC(305-380) [nucleoplasm] (R-HSA-6782614) Ub-538-UBC(533-608) [nucleoplasm] (R-HSA-6782664) Ub-462-UBC(457-532) [nucleoplasm] (R-HSA-6782634) Ub-386-UBC(381-456) [nucleoplasm] (R-HSA-6782605) Ub-614-UBC(609-684) [nucleoplasm] (R-HSA-6782657) UBC(229-304) [nucleoplasm] (R-HSA-939857) UBC(381-456) [nucleoplasm] (R-HSA-939856) UBC(305-380) [nucleoplasm] (R-HSA-939863) UBC(457-532) [nucleoplasm] (R-HSA-939862) UBC(533-608) [nucleoplasm] (R-HSA-939866) UBC(77-152) [nucleoplasm] (R-HSA-939869) UBC(609-684) [nucleoplasm] (R-HSA-939868) UBC(1-76) [nucleoplasm] (R-HSA-939871) UBC(153-228) [nucleoplasm] (R-HSA-939853) Ub-124-UBC(77-152) [nucleoplasm] (R-HSA-5683048) Ub-580-UBC(533-608) [nucleoplasm] (R-HSA-5683050) Ub-428-UBC(381-456) [nucleoplasm] (R-HSA-5683041) Ub-276-UBC(229-304) [nucleoplasm] (R-HSA-5683042) Ub-352-UBC(305-380) [nucleoplasm] (R-HSA-5683045) Ub-200-UBC(153-228) [nucleoplasm] (R-HSA-5683046) Ub-48-UBC(1-76) [nucleoplasm] (R-HSA-5683033) Ub-656-UBC(609-684) [nucleoplasm] (R-HSA-5683035) Ub-504-UBC(457-532) [nucleoplasm] (R-HSA-5683039) Ub-671-UBC(609-684) [nucleoplasm] (R-HSA-6782523) Ub-215-UBC(153-228) [nucleoplasm] (R-HSA-6782491) Ub-63-UBC(1-76) [nucleoplasm] (R-HSA-6782492) Ub-443-UBC(381-456) [nucleoplasm] (R-HSA-6782480) Ub-367-UBC(305-380) [nucleoplasm] (R-HSA-6782479) Ub-139-UBC(77-152) [nucleoplasm] (R-HSA-6782496) Ub-519-UBC(457-532) [nucleoplasm] (R-HSA-6782497) Ub-595-UBC(533-608) [nucleoplasm] (R-HSA-6782499) Ub-291-UBC(229-304) [nucleoplasm] (R-HSA-6782500) UBC(609-684) [late endosome lumen] (R-HSA-9660012) UBC(153-228) [late endosome lumen] (R-HSA-9659979) UBC(305-380) [late endosome lumen] (R-HSA-9660033) UBC(77-152) [late endosome lumen] (R-HSA-9659992) UBC(533-608) [late endosome lumen] (R-HSA-9659993) UBC(229-304) [late endosome lumen] (R-HSA-9659994) UBC(457-532) [late endosome lumen] (R-HSA-9659995) UBC(381-456) [late endosome lumen] (R-HSA-9660023) UBC(1-76) [late endosome lumen] (R-HSA-9659985) Ub-48-UBC(1-76) [cytosol] (R-HSA-939219) Ub-656-UBC(609-684) [cytosol] (R-HSA-939255) Ub-428-UBC(381-456) [cytosol] (R-HSA-939190) Ub-504-UBC(457-532) [cytosol] (R-HSA-939257) Ub-580-UBC(533-608) [cytosol] (R-HSA-939256) Ub-276-UBC(229-304) [cytosol] (R-HSA-939207) Ub-124-UBC(77-152) [cytosol] (R-HSA-939209) Ub-200-UBC(153-228) [cytosol] (R-HSA-939179) Ub-352-UBC(305-380) [cytosol] (R-HSA-939181) UBC(457-532) [cytosol] (R-HSA-939184) UBC(1-76) [cytosol] (R-HSA-939188) UBC(381-456) [cytosol] (R-HSA-939191) UBC(229-304) [cytosol] (R-HSA-939192) UBC(153-228) [cytosol] (R-HSA-939258) UBC(609-684) [cytosol] (R-HSA-939165) UBC(77-152) [cytosol] (R-HSA-939164) UBC(305-380) [cytosol] (R-HSA-939232) UBC(533-608) [cytosol] (R-HSA-939239) UBC(1-76) [lysosomal lumen] (R-HSA-9659981) UBC(305-380) [lysosomal lumen] (R-HSA-9660008) UBC(77-152) [lysosomal lumen] (R-HSA-9659978) UBC(609-684) [lysosomal lumen] (R-HSA-9660020) UBC(153-228) [lysosomal lumen] (R-HSA-9659988) UBC(457-532) [lysosomal lumen] (R-HSA-9659989) UBC(381-456) [lysosomal lumen] (R-HSA-9659984) UBC(229-304) [lysosomal lumen] (R-HSA-9660018) UBC(533-608) [lysosomal lumen] (R-HSA-9659987) Ub-215-UBC(153-228) [cytosol] (R-HSA-939186) Ub-139-UBC(77-152) [cytosol] (R-HSA-939254) Ub-595-UBC(533-608) [cytosol] (R-HSA-939198) Ub-291-UBC(229-304) [cytosol] (R-HSA-939173) Ub-367-UBC(305-380) [cytosol] (R-HSA-939206) Ub-671-UBC(609-684) [cytosol] (R-HSA-939241) Ub-63-UBC(1-76) [cytosol] (R-HSA-939176) Ub-519-UBC(457-532) [cytosol] (R-HSA-939212) Ub-443-UBC(381-456) [cytosol] (R-HSA-939182)	0.524	3
UniProt:Q13635 PTCH1	4	ub-PTCH1 [endocytic vesicle membrane] (R-HSA-5632520) PTCH1 [plasma membrane] (R-HSA-445133) ub-PTCH1 [ciliary membrane] (R-HSA-5632517) PTCH1 [ciliary membrane] (R-HSA-5610415)	0.499	2
UniProt:P21462 FPR1	4	FPR1 [secretory granule membrane] (R-HSA-6800929) FPR1 [ficolin-1-rich granule membrane] (R-HSA-6800878) FPR1 [azurophil granule membrane] (R-HSA-6799143) FPR1 [plasma membrane] (R-HSA-375450)	0.499	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.463	5
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.463	3
UniProt:Q9UBN7 HDAC6	5	HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [cytosol] (R-HSA-9646404) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.463	2

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